Marco Mammana1, Giuseppe Marulli2, Andrea Zuin1, Egle Perissinotto3, Giovanni Maria Comacchio1, Elisa De Franceschi1, Federico Rea1. 1. Thoracic Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani, 2, 35128, Padua, Italy. 2. Thoracic Surgery Unit, Department of Emergency and Organ Transplantation, University Hospital of Bari, Piazza Giulio Cesare, 11, 70120, Bari, Italy. giuseppe.marulli@uniba.it. 3. Biostatistic Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani, 2, 35128, Padua, Italy.
Abstract
PURPOSE: Bronchopleural fistula (BPF) is a potentially fatal complication of pneumonectomy. We analyze its occurrence rate, risk factors, and the methods used for its prevention. METHODS: We reviewed the medical records of patients who underwent pneumonectomy at our Institution between January, 1990 and March, 2016. The risk factors for postoperative BPF were analyzed by univariate analysis and multiple logistic regression. RESULTS: Over the study period, 511 patients underwent pneumonectomy for non-small cell lung cancer (NSCLC) and had the bronchus closed by manual suturing. BPF developed in 23 patients (4.5%). Multiple logistic regression identified no coverage of the bronchial stump, right-sided pneumonectomy, residual tumor in the bronchial stump, postoperative ventilatory support, and completion pneumonectomy, as independent risk factors for BPF. The cumulative rate of BPF decreased significantly over time from 18% between 1990 and 1995 to 1% between 2011 and 2016 (p < 0.001). Concurrently, the data of several patients showed a significant positive trend over time, including bronchial stump coverage (BSC). DISCUSSION: Several known risk factors for BPF were confirmed. The more frequent usage of tissue flaps for coverage of the bronchial stump may have contributed to the reduction in the rate of postoperative BPF over time.
PURPOSE:Bronchopleural fistula (BPF) is a potentially fatal complication of pneumonectomy. We analyze its occurrence rate, risk factors, and the methods used for its prevention. METHODS: We reviewed the medical records of patients who underwent pneumonectomy at our Institution between January, 1990 and March, 2016. The risk factors for postoperative BPF were analyzed by univariate analysis and multiple logistic regression. RESULTS: Over the study period, 511 patients underwent pneumonectomy for non-small cell lung cancer (NSCLC) and had the bronchus closed by manual suturing. BPF developed in 23 patients (4.5%). Multiple logistic regression identified no coverage of the bronchial stump, right-sided pneumonectomy, residual tumor in the bronchial stump, postoperative ventilatory support, and completion pneumonectomy, as independent risk factors for BPF. The cumulative rate of BPF decreased significantly over time from 18% between 1990 and 1995 to 1% between 2011 and 2016 (p < 0.001). Concurrently, the data of several patients showed a significant positive trend over time, including bronchial stump coverage (BSC). DISCUSSION: Several known risk factors for BPF were confirmed. The more frequent usage of tissue flaps for coverage of the bronchial stump may have contributed to the reduction in the rate of postoperative BPF over time.
Authors: C Deschamps; A Bernard; F C Nichols; M S Allen; D L Miller; V F Trastek; G D Jenkins; P C Pairolero Journal: Ann Thorac Surg Date: 2001-07 Impact factor: 4.330
Authors: Shahrokh Taghavi; Gabriel M Marta; Georg Lang; Gernot Seebacher; Gunther Winkler; Katharina Schmid; Walter Klepetko Journal: Ann Thorac Surg Date: 2005-01 Impact factor: 4.330
Authors: Giorgio Lo Iacono; Elena Prisciandaro; Shehab Mohamed; Luca Bertolaccini; Lara Girelli; Giulia Sedda; Antonio Mazzella; Juliana Guarize; Stefano Donghi; Lorenzo Spaggiari Journal: Indian J Thorac Cardiovasc Surg Date: 2022-06-27