Akiko Narita1, Takahiro Yamamoto2, Shuji Ikeda2, Yuichiro Izumi2, Akira Kitagawa2, Mansaku Takeda3, Kenta Murotani4, Makiyo Hagihara2, Toyohiro Ota2, Tsuneo Ishiguchi2, Kojiro Suzuki2. 1. Department of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. narita.akiko.046@mail.aichi-med-u.ac.jp. 2. Department of Radiology, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. 3. Department of Radiological Technology, Aichi Medical University Hospital, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. 4. Biostatistics Center, Graduate School of Medicine, Kurume University, 67 Asahi-Machi, Kurume, Fukuoka, 830-0011, Japan.
Abstract
PURPOSE: To evaluate the radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) under X-ray imaging. MATERIALS AND METHODS: SAP-MS were suspended in contrast material (iodixanol) and the diameter change was assessed. The diameter of contrast-loaded SAP-MS in saline was measured sequentially. Radiography of the contrast-loaded SAP-MS was evaluated as radiopacity by contrast-to-noise ratio and visibility by multiple reader scoring. Under digital subtraction angiography, contrast-loaded SAP-MS were injected into a flow model. The flow speed was 1-10 cm/s, and images were acquired at 1-7.5 frames per second using a pulse width of 10-85 ms. Images were assessed by multiple reader scoring. RESULTS: The diameter of SAP-MS increased to 4.0-5.0 times its original size for approximately 15 min. The diameter of contrast-loaded SAP-MS in saline further increased by 10-30% within several minutes and returned to the previous size. Radiopacity and visibility of contrast-loaded SAP-MS decreased in 30 min after mixing with saline. Visibility was better with slow flow speed and narrow pulse width. CONCLUSION: For effective observation, contrast-loaded SAP-MS should be kept in non-diluted contrast material until use. The conditions of slower flow and use of a narrow pulse width are recommended.
PURPOSE: To evaluate the radiopacity of contrast-loaded superabsorbent polymer microspheres (SAP-MS) under X-ray imaging. MATERIALS AND METHODS:SAP-MS were suspended in contrast material (iodixanol) and the diameter change was assessed. The diameter of contrast-loaded SAP-MS in saline was measured sequentially. Radiography of the contrast-loaded SAP-MS was evaluated as radiopacity by contrast-to-noise ratio and visibility by multiple reader scoring. Under digital subtraction angiography, contrast-loaded SAP-MS were injected into a flow model. The flow speed was 1-10 cm/s, and images were acquired at 1-7.5 frames per second using a pulse width of 10-85 ms. Images were assessed by multiple reader scoring. RESULTS: The diameter of SAP-MS increased to 4.0-5.0 times its original size for approximately 15 min. The diameter of contrast-loaded SAP-MS in saline further increased by 10-30% within several minutes and returned to the previous size. Radiopacity and visibility of contrast-loaded SAP-MS decreased in 30 min after mixing with saline. Visibility was better with slow flow speed and narrow pulse width. CONCLUSION: For effective observation, contrast-loaded SAP-MS should be kept in non-diluted contrast material until use. The conditions of slower flow and use of a narrow pulse width are recommended.
Authors: Ashok K Gupta; Rendon C Nelson; G Allan Johnson; Erik K Paulson; David M Delong; Terry T Yoshizumi Journal: Radiology Date: 2003-04-17 Impact factor: 11.105
Authors: Y Jiaqi; S Hori; K Minamitani; T Hashimoto; H Yoshimura; N Nomura; T Ishida; H Fukuda; K Tomoda; H Nakamura Journal: Nihon Igaku Hoshasen Gakkai Zasshi Date: 1996-01
Authors: Rafael Duran; Karun Sharma; Matthew R Dreher; Koorosh Ashrafi; Sahar Mirpour; MingDe Lin; Ruediger E Schernthaner; Todd R Schlachter; Vania Tacher; Andrew L Lewis; Sean Willis; Mark den Hartog; Alessandro Radaelli; Ayele H Negussie; Bradford J Wood; Jean-François H Geschwind Journal: Theranostics Date: 2016-01-01 Impact factor: 11.556