Daniela Westerwick 1 , Thomas Hager 1 , Paul Buderath 2 , Fabian Mairinger 1 , Elena Mairinger 1 , Katharina Böhm 1 , Pawel Mach 3 , Kurt Werner Schmid 1 , Rainer Kimmig 3 , Sabine Kasimir-Bauer 3 , Agnes Bankfalvi 1 Show Affiliations »
Abstract
INTRODUCTION: Ovarian carcinoma is associated with the highest mortality of all gynecologic malignancies. Even after optimal treatment, prognosis remains poor. There is no established biomarker to predict individual patient outcome. OBJECTIVE: To evaluate the prognostic significance of PD-1 and PD-L1 expression in tumor tissues from patients with ovarian cancer. METHODS: Tissue micro-arrays were prepared from routinely formalin-fixed, paraffin-embedded tumor tissues and examined immunohistochemically for the expression of programed cell death protein 1 (PD-1) and one of its ligands (PD-L1) on epithelial tumor cells, as well as on tumor- and stroma-infiltrating immune cells. RESULTS: The presence of PD-1 positive tumor-infiltrating immune cells was significantly associated with prolonged overall survival. PD-1 and PD-L1 positive tumor-infiltrating immune cells were associated with the presence of lymph node metastases and higher tumor grade. Interestingly, the amount of PD-1/PD-L1 positive tumor- and stroma-infiltrating immune cells independent of PD-1 or PD-L1 expression did not show any significant correlation with prognostic variables. CONCLUSION: Our results highlight the prognostic value of PD-1 and PD-L1 positive tumor-infiltrating immune cells in ovarian carcinoma. Their association with favorable prognosis supports the hypothesis that the expression of PD-1 and PD-L1 on tumor-infiltrating immune cells represents a strong immune response. © IGCS and ESGO 2019. No commercial re-use. See rights and permissions. Published by BMJ.
INTRODUCTION: Ovarian carcinoma is associated with the highest mortality of all gynecologic malignancies . Even after optimal treatment, prognosis remains poor. There is no established biomarker to predict individual patient outcome. OBJECTIVE: To evaluate the prognostic significance of PD-1 and PD-L1 expression in tumor tissues from patients with ovarian cancer . METHODS: Tissue micro-arrays were prepared from routinely formalin -fixed, paraffin -embedded tumor tissues and examined immunohistochemically for the expression of programed cell death protein 1 (PD-1 ) and one of its ligands (PD-L1 ) on epithelial tumor cells, as well as on tumor - and stroma-infiltrating immune cells. RESULTS: The presence of PD-1 positive tumor -infiltrating immune cells was significantly associated with prolonged overall survival. PD-1 and PD-L1 positive tumor -infiltrating immune cells were associated with the presence of lymph node metastases and higher tumor grade. Interestingly, the amount of PD-1/PD-L1 positive tumor - and stroma-infiltrating immune cells independent of PD-1 or PD-L1 expression did not show any significant correlation with prognostic variables. CONCLUSION: Our results highlight the prognostic value of PD-1 and PD-L1 positive tumor -infiltrating immune cells in ovarian carcinoma . Their association with favorable prognosis supports the hypothesis that the expression of PD-1 and PD-L1 on tumor -infiltrating immune cells represents a strong immune response. © IGCS and ESGO 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Entities: Chemical
Disease
Gene
Species
Keywords:
cystadenocarcinoma; cystadenocarcinoma, serous; ovarian cancer; ovarian neoplasms; pathology
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Year: 2019
PMID： 31492714 DOI： 10.1136/ijgc-2019-000609
Source DB: PubMed Journal: Int J Gynecol Cancer ISSN： 1048-891X Impact factor: 3.437