| Literature DB >> 31492428 |
Hideyuki Sasaki1, Toshiaki Sueyasu2, Hisanori Tokuda2, Mika Ito2, Yoshihisa Kaneda2, Tomohiro Rogi2, Hiroshi Kawashima3, Sayaka Horiguchi4, Terue Kawabata4, Hiroshi Shibata2.
Abstract
Long-chain polyunsaturated fatty acids (LCPUFAs) are important constituents of biomembranes. Observation of blood fatty acids indicated that LCPUFA biosynthesis is affected by aging and FADS polymorphisms. This study examined the effects of aging and FADS polymorphisms on LCPUFA biosynthetic capacity via direct quantification using [U-13C]linoleic acid. Healthy young (25-34 years) and elderly (65-74 years) participants were administered [U-13C]linoleate, and its metabolites were monitored for 14 days. The time of maximum plasma concentration of 13C-arachidonic acid (ARA) was 4-5 days. The area under the curve of the 13C-ARA concentration differed by FADS1 rs174547 polymorphism (TT [100%] > TC [57%] > CC [37%]). Among C allele carriers, 13C-ARA formation was 32% lower in elderly than in young participants. This is the first report to directly demonstrate that LCPUFA biosynthetic capacity is regulated by FADS1 polymorphisms and decreased by aging in FADS1 C allele carriers.Entities:
Keywords: Aging; Arachidonic acid; Fatty acid conversion; Linoleic acid; Lipid metabolism; Long-chain polyunsaturated fatty acid
Mesh：
Substances：
Year: 2019 PMID： 31492428 DOI： 10.1016/j.plefa.2019.07.003
Source DB: PubMed Journal: Prostaglandins Leukot Essent Fatty Acids ISSN： 0952-3278 Impact factor: 4.006