Literature DB >> 3149123

Chromatolytic neurons in Werdnig-Hoffmann disease contain phosphorylated neurofilaments.

C F Lippa1, T W Smith.   

Abstract

Two cases of Werdnig-Hoffman disease are described. Chromatolytic neurons were found within the ventral horns of the spinal cord as well as in dorsal root ganglia, Clarke's column, cranial nerve nuclei and thalamus. Immunohistochemical staining demonstrated phosphorylated neurofilament antigen within the cytoplasm of the chromatolytic neurons. This finding suggests that a defect in slow axonal transport or in the regulation of neurofilament phosphorylation may play a role in the pathogenesis of this disorder.

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Year:  1988        PMID： 3149123     DOI： 10.1007/bf00688247

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  9 in total

1.  Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients.

Authors:  D G Munoz; C Greene; D P Perl; D J Selkoe
Journal:  J Neuropathol Exp Neurol       Date:  1988-01       Impact factor: 3.685

2.  "Chromatolytic" neurons in lateral geniculate body in Werdnig-Hoffmann disease.

Authors:  N S Peress; A B Stermann; R Miller; C G Kaplan; B W Little
Journal:  Clin Neuropathol       Date:  1986 Mar-Apr       Impact factor: 1.368

3.  A neuropathologic study of Werdnig-Hoffmann disease with special reference to the thalamus and posterior roots.

Authors:  K Shishikura; M Hara; Y Sasaki; K Misugi
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088

4.  Is Werdnig-Hoffmann disease a pure lower motor neuron disorder?

Authors:  J Towfighi; R S Young; R M Ward
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088

5.  Infantile neuronal degeneration masquerading as Werdnig-Hoffmann disease.

Authors:  G S Steiman; L B Rorke; M J Brown
Journal:  Ann Neurol       Date:  1980-09       Impact factor: 10.422

6.  Werdnig-Hoffmann disease: proposal of a pathogenetic mechanism.

Authors:  S M Chou; I Nonaka
Journal:  Acta Neuropathol       Date:  1978-01-19       Impact factor: 17.088

7.  Infantile neurodegenerative disease with neuronal accumulation of phosphorylated neurofilaments.

Authors:  C A Wiley; S Love; R R Skoglund; P W Lampert
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

8.  Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes.

Authors:  D W Dickson; S H Yen; K I Suzuki; P Davies; J H Garcia; A Hirano
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

9.  Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls.

Authors:  M L Schmidt; M J Carden; V M Lee; J Q Trojanowski
Journal:  Lab Invest       Date:  1987-03       Impact factor: 5.662
  9 in total
  4 in total

1.  Failure of lower motor neuron radial outgrowth precedes retrograde degeneration in a feline model of spinal muscular atrophy.

Authors:  Erin N Wakeling; Béatrice Joussemet; Patrick Costiou; Dominique Fanuel; Philippe Moullier; Martine Barkats; John C Fyfe
Journal:  J Comp Neurol       Date:  2012-06-01       Impact factor: 3.215

2.  Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells.

Authors:  G Sobue; Y Hashizume; T Yasuda; E Mukai; T Kumagai; T Mitsuma; J Q Trojanowski
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

3.  Ubiquitin and phosphorylated neurofilament epitopes in ballooned neurons of the extraocular muscle nuclei in a case of Werdnig-Hoffmann disease.

Authors:  S Kato; A Hirano
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

4.  Immunocytochemical and ultrastructural studies of Werdnig-Hoffmann disease.

Authors:  S Murayama; T W Bouldin; K Suzuki
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088
  4 in total

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