Literature DB >> 31488508

RUNX transcription factors: orchestrators of development.

Renaud Mevel1, Julia E Draper1, Michael Lie-A-Ling1, Valerie Kouskoff2, Georges Lacaud3.   

Abstract

RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
© 2019. Published by The Company of Biologists Ltd.

Entities:  

Keywords:  Bone; Development; Embryonic; Hematopoiesis; RUNX; T cell

Mesh：

Substances：

Year:  2019        PMID： 31488508     DOI： 10.1242/dev.148296

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  52 in total

1.  Expression of BSP-GFPtpz Transgene during Osteogenesis and Reparative Dentinogenesis.

Authors:  A Vijaykumar; P Dyrkacz; I Vidovic-Zdrilic; P Maye; M Mina
Journal:  J Dent Res       Date:  2019-11-04       Impact factor: 6.116

Review 2.  Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA).

Authors:  Anna L Brown; Christopher N Hahn; Hamish S Scott
Journal:  Blood       Date:  2020-07-02       Impact factor: 22.113

3.  A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation.

Authors:  Amanda G Davis; Jaclyn M Einstein; Dinghai Zheng; Nathan D Jayne; Xiang-Dong Fu; Bin Tian; Gene W Yeo; Dong-Er Zhang
Journal:  Blood Adv       Date:  2021-03-09

Review 4.  Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary.

Authors:  Chuyu Xiao; Jing Wang; Chunping Zhang
Journal:  Reprod Sci       Date:  2022-04-06       Impact factor: 3.060

5.  Upregulation of Runt related transcription factor 1 (RUNX1) contributes to tendon-bone healing after anterior cruciate ligament reconstruction using bone mesenchymal stem cells.

Authors:  Kai Kang; Qian Geng; Lukuan Cui; Lijie Wu; Lei Zhang; Tong Li; Qian Zhang; Shijun Gao
Journal:  J Orthop Surg Res       Date:  2022-05-13       Impact factor: 2.677

6.  RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression.

Authors:  Daniel J Kim; William Khoury-Hanold; Priyanka Caroline Jain; Jonathan Klein; Yong Kong; Scott D Pope; William Ge; Ruslan Medzhitov; Akiko Iwasaki
Journal:  J Virol       Date:  2020-10-27       Impact factor: 5.103

7.  Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling.

Authors:  Dana C Bellissimo; Chia-Hui Chen; Qin Zhu; Sumedha Bagga; Chung-Tsai Lee; Bing He; Gerald B Wertheim; Martha Jordan; Kai Tan; G Scott Worthen; D Gary Gilliland; Nancy A Speck
Journal:  Blood Adv       Date:  2020-03-24

8.  Deep neural networks identify sequence context features predictive of transcription factor binding.

Authors:  An Zheng; Michael Lamkin; Hanqing Zhao; Cynthia Wu; Hao Su; Melissa Gymrek
Journal:  Nat Mach Intell       Date:  2021-01-18

9.  Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching.

Authors:  Boyoung Shin; Hiroyuki Hosokawa; Maile Romero-Wolf; Wen Zhou; Kaori Masuhara; Victoria R Tobin; Ditsa Levanon; Yoram Groner; Ellen V Rothenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2021-01-26       Impact factor: 12.779

10.  Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets.

Authors:  Matthew R Hass; Daniel Brissette; Sreeja Parameswaran; Mario Pujato; Omer Donmez; Leah C Kottyan; Matthew T Weirauch; Raphael Kopan
Journal:  PLoS Genet       Date:  2021-06-10       Impact factor: 6.020
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