Jiean Joseph Heifetz-Li1, Samer Abdelsamie2, Conor B Campbell3, Stephanie Roth4, Allen F Fielding5, Joseph P Mulligan2. 1. Oral and Maxillofacial Surgery, Temple University Hospitals, Philadelphia, PA, USA. Electronic address: Jieanjoseph.li@tuhs.temple.edu. 2. Oral and Maxillofacial Surgery, Temple University Hospitals, Philadelphia, PA, USA. 3. Temple University School of Dentistry, Philadelphia, PA, USA. 4. Temple University Libraries, Philadelphia, PA, USA. 5. Oral and Maxillofacial Surgery, Temple University Hospitals, Philadelphia, PA, USA; Temple University School of Dentistry, Philadelphia, PA, USA.
Abstract
OBJECTIVE: Medication-related osteonecrosis of the jaw (MRONJ) is a pathologic process resulting in progressive destruction of the jaws. There are no established guidelines for the medical management of MRONJ. Interest in pentoxifylline and tocopherol is growing because these agents have been shown to be effective in treating osteoradionecrosis of the jaw. This review evaluates the clinical usefulness of pentoxifylline and tocopherol in treating MRONJ. STUDY DESIGN: Literature databases were searched for relevant reports of pentoxifylline and tocopherol in treating MRONJ. Only English-language reports and human studies were considered. RESULTS: There were 3 published observational studies and 2 abstracts relevant to this topic. The combination of pentoxifylline and tocopherol is associated with subjective and objective improvements and no major adverse outcomes. CONCLUSIONS: Pentoxifylline and tocopherol has been demonstrated to be effective for managing MRONJ nonsurgically, and, thus, this treatment modality holds promise. However, larger clinical studies are needed to optimize dose and duration.
OBJECTIVE: Medication-related osteonecrosis of the jaw (MRONJ) is a pathologic process resulting in progressive destruction of the jaws. There are no established guidelines for the medical management of MRONJ. Interest in pentoxifylline and tocopherol is growing because these agents have been shown to be effective in treating osteoradionecrosis of the jaw. This review evaluates the clinical usefulness of pentoxifylline and tocopherol in treating MRONJ. STUDY DESIGN: Literature databases were searched for relevant reports of pentoxifylline and tocopherol in treating MRONJ. Only English-language reports and human studies were considered. RESULTS: There were 3 published observational studies and 2 abstracts relevant to this topic. The combination of pentoxifylline and tocopherol is associated with subjective and objective improvements and no major adverse outcomes. CONCLUSIONS:Pentoxifylline and tocopherol has been demonstrated to be effective for managing MRONJ nonsurgically, and, thus, this treatment modality holds promise. However, larger clinical studies are needed to optimize dose and duration.
Authors: Guillermo Pardo-Zamora; Yanet Martínez; Jose Antonio Moreno; Antonio J Ortiz-Ruíz Journal: Int J Environ Res Public Health Date: 2021-01-24 Impact factor: 3.390
Authors: Darya A Kizub; Jieling Miao; Mark M Schubert; Alexander H G Paterson; Mark Clemons; Elizabeth C Dees; James N Ingle; Carla I Falkson; William E Barlow; Gabriel N Hortobagyi; Julie R Gralow Journal: Support Care Cancer Date: 2020-09-15 Impact factor: 3.603