Philippe Desmarais1, Danielle Weidman2, Andréanne Wassef3, Marie-Andrée Bruneau4, Jess Friedland5, Paulina Bajsarowicz5, Marie-Pierre Thibodeau6, Nathan Herrmann7, Quoc Dinh Nguyen8. 1. Department of Medicine, Division of Geriatrics (PD, MPT,QDN), Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Department of Neurosciences (PD, MPT), Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada. Electronic address: philippe.desmarais.1@umontreal.ca. 2. Department of Pediatrics (DW), The Hospital for Sick Children, Toronto, Ontario, Canada. 3. Department of Psychiatry (AW), Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada. 4. Centre de Recherche, Institut Universitaire de Gériatrie de Montréal (MAB), Montréal, Québec, Canada. 5. Department of Psychiatry, Division of Geriatric Psychiatry (JF), Douglas Mental Health University Institute, Montréal, Québec, Canada. 6. Department of Medicine, Division of Geriatrics (PD, MPT,QDN), Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Department of Neurosciences (PD, MPT), Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada. 7. Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto (NH), Toronto, Ontario, Canada; Department of Psychiatry (NH), University of Toronto, Toronto, Ontario, Canada. 8. Department of Medicine, Division of Geriatrics (PD, MPT,QDN), Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada; Innovation Hub, Centre de Recherche du Centre Hospitalier de l'Université de Montréal (QDN), Montréal, Québec, Canada.
Abstract
BACKGROUND: Post-traumatic stress disorder (PTSD) has been reported to increase the risk for dementia in veterans and civilians. Conversely, case reports have described the delayed onset of PTSD in individuals developing dementia, suggesting a complex relationship between these two conditions. OBJECTIVES: To critically review studies investigating the association between PTSD and dementia and to assess the evidence for a bidirectional relationship between the two conditions. METHODS: A systematic review of Web of Science Core databases was carried out from inception of databases up to November 2018 to identify observational studies pertaining to both PTSD and dementia. Populations enrolled, stressors and neuropathologies, and main outcomes of studies were extracted, in addition to age at trauma and at onset of PTSD and dementia. The different temporal relationships between trauma and onset of the conditions were characterized. RESULTS: Twenty-five articles were included in the review; 14 articles assessed the association of PTSD with subsequent dementia and 11 articles reported the delayed onset of PTSD with the onset of dementia. Most reported traumas occurred in early-life (<40 years) and were related to war combat experiences. PTSD in mid-life (between 40 and 60 years of age) was associated with an increased risk of late-onset dementia. Numerous case series reported the delayed onset of PTSD in Alzheimer's disease and vascular dementia. CONCLUSION: Current evidence suggests that PTSD and dementia have a bidirectional relationship: PTSD increases the risk for late-onset dementia and dementia increases the risk for delayed-onset PTSD in those who experienced a significant trauma earlier in life.
BACKGROUND: Post-traumatic stress disorder (PTSD) has been reported to increase the risk for dementia in veterans and civilians. Conversely, case reports have described the delayed onset of PTSD in individuals developing dementia, suggesting a complex relationship between these two conditions. OBJECTIVES: To critically review studies investigating the association between PTSD and dementia and to assess the evidence for a bidirectional relationship between the two conditions. METHODS: A systematic review of Web of Science Core databases was carried out from inception of databases up to November 2018 to identify observational studies pertaining to both PTSD and dementia. Populations enrolled, stressors and neuropathologies, and main outcomes of studies were extracted, in addition to age at trauma and at onset of PTSD and dementia. The different temporal relationships between trauma and onset of the conditions were characterized. RESULTS: Twenty-five articles were included in the review; 14 articles assessed the association of PTSD with subsequent dementia and 11 articles reported the delayed onset of PTSD with the onset of dementia. Most reported traumas occurred in early-life (<40 years) and were related to war combat experiences. PTSD in mid-life (between 40 and 60 years of age) was associated with an increased risk of late-onset dementia. Numerous case series reported the delayed onset of PTSD in Alzheimer's disease and vascular dementia. CONCLUSION: Current evidence suggests that PTSD and dementia have a bidirectional relationship: PTSD increases the risk for late-onset dementia and dementia increases the risk for delayed-onset PTSD in those who experienced a significant trauma earlier in life.
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