Literature DB >> 3148818

Characterization of a silent pilin gene locus from Neisseria meningitidis strain FAM18.

E L Aho1, J G Cannon.   

Abstract

We cloned and characterized a silent pilin locus (pilS) in the chromosome of Neisseria meningitidis strain FAM18. This locus represents the sole region of the FAM18 chromosome with strong homology to a gonococcal pilin gene. The FAM18 pilS locus encodes two tandem, in-frame, truncated pilin genes and shares many features with the previously described pilS locus of N. meningitidis strain C114. However, DNA sequence comparison shows that different information resides in the hypervariable region of one of the gene copies between the two strains. The conservation of reading frames within silent copies and the sequence diversity in hypervariable regions are reminiscent of gonococcal pilS loci and suggest that pilS loci may be of functional importance in the meningococcus.

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Year:  1988        PMID： 3148818     DOI： 10.1016/0882-4010(88)90039-3

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  7 in total

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Authors:  B A Sampson; E C Gotschlich
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2.  Frequency and rate of pilin antigenic variation of Neisseria meningitidis.

Authors:  R Allen Helm; H Steven Seifert
Journal:  J Bacteriol       Date:  2010-05-14       Impact factor: 3.490

3.  The physical map of the chromosome of a serogroup A strain of Neisseria meningitidis shows complex rearrangements relative to the chromosomes of the two mapped strains of the closely related species N. gonorrhoeae.

Authors:  J A Dempsey; A B Wallace; J G Cannon
Journal:  J Bacteriol       Date:  1995-11       Impact factor: 3.490

4.  Characterization of a class II pilin expression locus from Neisseria meningitidis: evidence for increased diversity among pilin genes in pathogenic Neisseria species.

Authors:  E L Aho; J W Botten; R J Hall; M K Larson; J K Ness
Journal:  Infect Immun       Date:  1997-07       Impact factor: 3.441

5.  Evidence for functionally distinct pili expressed by Neisseria meningitidis.

Authors:  R W Pinner; P A Spellman; D S Stephens
Journal:  Infect Immun       Date:  1991-09       Impact factor: 3.441

6.  The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'.

Authors:  Lori A S Snyder; Nigel J Saunders
Journal:  BMC Genomics       Date:  2006-05-30       Impact factor: 3.969

7.  Contribution of σ70 and σN Factors to Expression of Class II pilE in Neisseria meningitidis.

Authors:  Mariya Lobanovska; Christoph M Tang; Rachel M Exley
Journal:  J Bacteriol       Date:  2019-09-20       Impact factor: 3.490
  7 in total

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