Anna Peguero1, Rafael Alonso Parra2, Sara Paola Carrillo2, Jose Rojas-Suarez3, Francesc Figueras4. 1. BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia Fetal i+D Fetal Medicine Research Center, Barcelona, Catalonia, Spain. 2. Obstetrical High-Dependency Unit; E.S.E. Hospital San Rafael de Facatativa, Colombia. 3. Obstetrics, Gynecology and Critical Care Departments, Universidad de Cartagena, Colombia. 4. BCNatal. Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Institut Clínic de Ginecologia, Obstetricia i Neonatologia Fetal i+D Fetal Medicine Research Center, Barcelona, Catalonia, Spain. Electronic address: ffiguera@clinic.ub.es.
Abstract
OBJECTIVE: To evaluate in women with severe preeclampsia the association of lactate concentration at admission with maternal complications. METHODS: A prospective cohort was created of women with severe preeclampsia consecutively admitted to an Obstetrical High-Dependency Unit. Plasma lactate concentration was measured at admission and its association to maternal complication was evaluated. RESULTS: A total of 100 women were included, of which 30 (30%) had a maternal complication. The mean lactate plasma concentration in this group was significantly higher than in those uncomplicated cases (2.38 vs 3.1 mmol/L; p < 0.01). A total of 37 (37%) women had lactate concentrations at >3 mmol/L, which was associated to higher incidence of maternal complications (19% vs. 48.6%; p = 0.002; OR 4.03 [95% CI 1.64-9.9]). This association remained independent of other standard severity criteria (OR 3.89; 95%CI 1.22-12.4; p = 0.022). CONCLUSION: Increased plasma lactate concentrations at admission in women with severe preeclampsia are independently associated to maternal complications.
OBJECTIVE: To evaluate in women with severe preeclampsia the association of lactate concentration at admission with maternal complications. METHODS: A prospective cohort was created of women with severe preeclampsia consecutively admitted to an Obstetrical High-Dependency Unit. Plasma lactate concentration was measured at admission and its association to maternal complication was evaluated. RESULTS: A total of 100 women were included, of which 30 (30%) had a maternal complication. The mean lactate plasma concentration in this group was significantly higher than in those uncomplicated cases (2.38 vs 3.1 mmol/L; p < 0.01). A total of 37 (37%) women had lactate concentrations at >3 mmol/L, which was associated to higher incidence of maternal complications (19% vs. 48.6%; p = 0.002; OR 4.03 [95% CI 1.64-9.9]). This association remained independent of other standard severity criteria (OR 3.89; 95%CI 1.22-12.4; p = 0.022). CONCLUSION: Increased plasma lactate concentrations at admission in women with severe preeclampsia are independently associated to maternal complications.