Xingnan Li1. 1. Division of Genetics, Genomics and Precision Medicine, Department of Medicine, University of Arizona, 1230 N Cherry Avenue, PO Box 210242, Tucson, AZ, 85719, USA. lixingnan1@deptofmed.arizona.edu.
Abstract
PURPOSE OF REVIEW: Asthma is a common inflammatory airway disease, which affects more than 300 million people worldwide. Although conventional drugs are effective for most of the patients with mild-to-moderate asthma, they are less effective for patients with difficult-to-treat or severe asthma. Identification of asthma endotypes and biomarkers will lead to more precise approaches to treat asthma. RECENT FINDINGS: Asthma subphenotypes and endotypes have been described based on clinical variables and sputum granulocytes. A recent asthma endotype study has been summarized based on the combination of T2 (FeNO) and non-T2 (IL-6) biomarkers. Discovery of potential biomarkers for asthma has been discussed in the context of omics approaches. Current biologic drugs for asthma have been summarized, and the future direction of precise treatment of asthma has been suggested. This review provides a concise overview of the current state of subphenotypes, endotypes, biomarkers, omics approaches, and biologic drugs in asthma.
PURPOSE OF REVIEW: Asthma is a common inflammatory airway disease, which affects more than 300 million people worldwide. Although conventional drugs are effective for most of the patients with mild-to-moderate asthma, they are less effective for patients with difficult-to-treat or severe asthma. Identification of asthma endotypes and biomarkers will lead to more precise approaches to treat asthma. RECENT FINDINGS:Asthma subphenotypes and endotypes have been described based on clinical variables and sputum granulocytes. A recent asthma endotype study has been summarized based on the combination of T2 (FeNO) and non-T2 (IL-6) biomarkers. Discovery of potential biomarkers for asthma has been discussed in the context of omics approaches. Current biologic drugs for asthma have been summarized, and the future direction of precise treatment of asthma has been suggested. This review provides a concise overview of the current state of subphenotypes, endotypes, biomarkers, omics approaches, and biologic drugs in asthma.
Authors: Wendy C Moore; Annette T Hastie; Xingnan Li; Huashi Li; William W Busse; Nizar N Jarjour; Sally E Wenzel; Stephen P Peters; Deborah A Meyers; Eugene R Bleecker Journal: J Allergy Clin Immunol Date: 2013-12-09 Impact factor: 10.793
Authors: Annette T Hastie; Wendy C Moore; Deborah A Meyers; Penny L Vestal; Huashi Li; Stephen P Peters; Eugene R Bleecker Journal: J Allergy Clin Immunol Date: 2010-04-15 Impact factor: 10.793
Authors: Xingnan Li; Elizabeth J Ampleford; Timothy D Howard; Wendy C Moore; Dara G Torgerson; Huashi Li; William W Busse; Mario Castro; Serpil C Erzurum; Elliot Israel; Dan L Nicolae; Carole Ober; Sally E Wenzel; Gregory A Hawkins; Eugene R Bleecker; Deborah A Meyers Journal: J Allergy Clin Immunol Date: 2012-06-12 Impact factor: 10.793
Authors: Wendy C Moore; Deborah A Meyers; Sally E Wenzel; W Gerald Teague; Huashi Li; Xingnan Li; Ralph D'Agostino; Mario Castro; Douglas Curran-Everett; Anne M Fitzpatrick; Benjamin Gaston; Nizar N Jarjour; Ronald Sorkness; William J Calhoun; Kian Fan Chung; Suzy A A Comhair; Raed A Dweik; Elliot Israel; Stephen P Peters; William W Busse; Serpil C Erzurum; Eugene R Bleecker Journal: Am J Respir Crit Care Med Date: 2009-11-05 Impact factor: 21.405
Authors: Zhaozhong Zhu; Phil H Lee; Mark D Chaffin; Wonil Chung; Po-Ru Loh; Quan Lu; David C Christiani; Liming Liang Journal: Nat Genet Date: 2018-05-21 Impact factor: 38.330
Authors: Florence Demenais; Patricia Margaritte-Jeannin; Kathleen C Barnes; William O C Cookson; Janine Altmüller; Wei Ang; R Graham Barr; Terri H Beaty; Allan B Becker; John Beilby; Hans Bisgaard; Unnur Steina Bjornsdottir; Eugene Bleecker; Klaus Bønnelykke; Dorret I Boomsma; Emmanuelle Bouzigon; Christopher E Brightling; Myriam Brossard; Guy G Brusselle; Esteban Burchard; Kristin M Burkart; Andrew Bush; Moira Chan-Yeung; Kian Fan Chung; Alexessander Couto Alves; John A Curtin; Adnan Custovic; Denise Daley; Johan C de Jongste; Blanca E Del-Rio-Navarro; Kathleen M Donohue; Liesbeth Duijts; Celeste Eng; Johan G Eriksson; Martin Farrall; Yuliya Fedorova; Bjarke Feenstra; Manuel A Ferreira; Maxim B Freidin; Zofia Gajdos; Jim Gauderman; Ulrike Gehring; Frank Geller; Jon Genuneit; Sina A Gharib; Frank Gilliland; Raquel Granell; Penelope E Graves; Daniel F Gudbjartsson; Tari Haahtela; Susan R Heckbert; Dick Heederik; Joachim Heinrich; Markku Heliövaara; John Henderson; Blanca E Himes; Hiroshi Hirose; Joel N Hirschhorn; Albert Hofman; Patrick Holt; Jouke Hottenga; Thomas J Hudson; Jennie Hui; Medea Imboden; Vladimir Ivanov; Vincent W V Jaddoe; Alan James; Christer Janson; Marjo-Riitta Jarvelin; Deborah Jarvis; Graham Jones; Ingileif Jonsdottir; Pekka Jousilahti; Michael Kabesch; Mika Kähönen; David B Kantor; Alexandra S Karunas; Elza Khusnutdinova; Gerard H Koppelman; Anita L Kozyrskyj; Eskil Kreiner; Michiaki Kubo; Rajesh Kumar; Ashish Kumar; Mikko Kuokkanen; Lies Lahousse; Tarja Laitinen; Catherine Laprise; Mark Lathrop; Susanne Lau; Young-Ae Lee; Terho Lehtimäki; Sébastien Letort; Albert M Levin; Guo Li; Liming Liang; Laura R Loehr; Stephanie J London; Daan W Loth; Ani Manichaikul; Ingo Marenholz; Fernando J Martinez; Melanie C Matheson; Rasika A Mathias; Kenji Matsumoto; Hamdi Mbarek; Wendy L McArdle; Mads Melbye; Erik Melén; Deborah Meyers; Sven Michel; Hamida Mohamdi; Arthur W Musk; Rachel A Myers; Maartje A E Nieuwenhuis; Emiko Noguchi; George T O'Connor; Ludmila M Ogorodova; Cameron D Palmer; Aarno Palotie; Julie E Park; Craig E Pennell; Göran Pershagen; Alexey Polonikov; Dirkje S Postma; Nicole Probst-Hensch; Valery P Puzyrev; Benjamin A Raby; Olli T Raitakari; Adaikalavan Ramasamy; Stephen S Rich; Colin F Robertson; Isabelle Romieu; Muhammad T Salam; Veikko Salomaa; Vivi Schlünssen; Robert Scott; Polina A Selivanova; Torben Sigsgaard; Angela Simpson; Valérie Siroux; Lewis J Smith; Maria Solodilova; Marie Standl; Kari Stefansson; David P Strachan; Bruno H Stricker; Atsushi Takahashi; Philip J Thompson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Carla M T Tiesler; Dara G Torgerson; Tatsuhiko Tsunoda; André G Uitterlinden; Ralf J P van der Valk; Amaury Vaysse; Sailaja Vedantam; Andrea von Berg; Erika von Mutius; Judith M Vonk; Johannes Waage; Nick J Wareham; Scott T Weiss; Wendy B White; Magnus Wickman; Elisabeth Widén; Gonneke Willemsen; L Keoki Williams; Inge M Wouters; James J Yang; Jing Hua Zhao; Miriam F Moffatt; Carole Ober; Dan L Nicolae Journal: Nat Genet Date: 2017-12-22 Impact factor: 38.330
Authors: Nick Shrine; Michael A Portelli; Catherine John; María Soler Artigas; Neil Bennett; Robert Hall; Jon Lewis; Amanda P Henry; Charlotte K Billington; Azaz Ahmad; Richard J Packer; Dominick Shaw; Zara E K Pogson; Andrew Fogarty; Tricia M McKeever; Amisha Singapuri; Liam G Heaney; Adel H Mansur; Rekha Chaudhuri; Neil C Thomson; John W Holloway; Gabrielle A Lockett; Peter H Howarth; Ratko Djukanovic; Jenny Hankinson; Robert Niven; Angela Simpson; Kian Fan Chung; Peter J Sterk; John D Blakey; Ian M Adcock; Sile Hu; Yike Guo; Maen Obeidat; Don D Sin; Maarten van den Berge; David C Nickle; Yohan Bossé; Martin D Tobin; Ian P Hall; Christopher E Brightling; Louise V Wain; Ian Sayers Journal: Lancet Respir Med Date: 2018-12-11 Impact factor: 30.700