François Lagacé1, Feras M Ghazawi2, Michelle Le1, Elham Rahme3, Evgeny Savin1, Andrei Zubarev1, Akram Alakel1, Denis Sasseville1, Linda Moreau1, Sarkis Meterissian4, Ivan V Litvinov5. 1. Division of Dermatology, McGill University, Rm. E02.6236, 1001 Decarie Blvd, Montréal, QC, H4A 3J1, Canada. 2. Division of Dermatology, University of Ottawa, Ottawa, ON, Canada. 3. Division of Clinical Epidemiology, McGill University, Montréal, QC, Canada. 4. Division of General Surgery, McGill University, Montréal, QC, Canada. 5. Division of Dermatology, McGill University, Rm. E02.6236, 1001 Decarie Blvd, Montréal, QC, H4A 3J1, Canada. ivan.litvinov@mcgill.ca.
Abstract
BACKGROUND/ PURPOSE: Breast cancer is the malignancy with the highest incidence rate excluding non-melanoma skin cancers, and the second leading cause of cancer-related deaths among Canadian women. Many modifiable risk factors have been linked to the pathogenesis of this disease. The purpose of this study is to analyze the epidemiology of breast cancer in Canada and to examine its geographic distribution to help identify new risk factors for this disease. METHODS: Three independent population-based cancer registries were used to retrospectively analyze demographic data from Canadian women diagnosed with invasive breast cancer across all provinces and territories between 1992 and 2010. The incidence and mortality rates were assessed at the provincial, city, and forward sortation area (FSA) postal code levels. RESULTS: The overall age-adjusted incidence rate was 114.4 cases per 100,000 females per year. Six provinces and several groups of FSAs had significantly higher incidence rates. There was a significant increase in incidence and decrease in mortality rates between 1992 and 2010. The overall mortality rate was 31.5 deaths per 100,000 females per year. However, three provinces had significantly higher mortality rates. CONCLUSION: By identifying high-incidence areas for breast cancer, our study will help identify patient populations that are at higher risk for this malignancy. It will also act as a foundation for future studies to establish novel risk factors for this disease.
BACKGROUND/ PURPOSE:Breast cancer is the malignancy with the highest incidence rate excluding non-melanoma skin cancers, and the second leading cause of cancer-related deaths among Canadian women. Many modifiable risk factors have been linked to the pathogenesis of this disease. The purpose of this study is to analyze the epidemiology of breast cancer in Canada and to examine its geographic distribution to help identify new risk factors for this disease. METHODS: Three independent population-based cancer registries were used to retrospectively analyze demographic data from Canadian women diagnosed with invasive breast cancer across all provinces and territories between 1992 and 2010. The incidence and mortality rates were assessed at the provincial, city, and forward sortation area (FSA) postal code levels. RESULTS: The overall age-adjusted incidence rate was 114.4 cases per 100,000 females per year. Six provinces and several groups of FSAs had significantly higher incidence rates. There was a significant increase in incidence and decrease in mortality rates between 1992 and 2010. The overall mortality rate was 31.5 deaths per 100,000 females per year. However, three provinces had significantly higher mortality rates. CONCLUSION: By identifying high-incidence areas for breast cancer, our study will help identify patient populations that are at higher risk for this malignancy. It will also act as a foundation for future studies to establish novel risk factors for this disease.
Authors: L Cattelan; F M Ghazawi; M Le; E Savin; A Zubarev; F Lagacé; D Sasseville; K Waschke; I V Litvinov Journal: Curr Oncol Date: 2020-06-01 Impact factor: 3.677
Authors: Matthew Castelo; Justin Lu; Lawrence Paszat; Zachary Veitch; Kuan Liu; Adena S Scheer Journal: Breast Cancer Res Treat Date: 2022-06-22 Impact factor: 4.624
Authors: Santina Conte; Feras M Ghazawi; Michelle Le; Hacene Nedjar; Akram Alakel; François Lagacé; Ilya M Mukovozov; Janelle Cyr; Ahmed Mourad; Wilson H Miller; Joël Claveau; Thomas G Salopek; Elena Netchiporouk; Robert Gniadecki; Denis Sasseville; Elham Rahme; Ivan V Litvinov Journal: Front Med (Lausanne) Date: 2022-03-03
Authors: Leila Cattelan; Feras M Ghazawi; Michelle Le; François Lagacé; Elham Rahme; Andrei Zubarev; Denis Sasseville; Ivan V Litvinov; Kevin A Waschke; Elena Netchiporouk Journal: Curr Oncol Date: 2021-05-28 Impact factor: 3.677
Authors: Leila Cattelan; Feras M Ghazawi; Michelle Le; François Lagacé; Evgeny Savin; Andrei Zubarev; Jennifer Gantchev; Marcel Tomaszewski; Denis Sasseville; Kevin Waschke; Ivan V Litvinov Journal: Cancer Med Date: 2019-11-12 Impact factor: 4.452