Literature DB >> 3148444

Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles.

C Thurieau1, J Brosius, C Burne, P Jolles, J H Keen, R J Mattaliano, E P Chow, K L Ramachandran, T Kirchhausen.   

Abstract

AP50 is the 50,000-dalton protein component found in clathrin-coated vesicles as part of the coat assembly protein (AP) complex, AP-2. AP50 cDNA clones were isolated from rat brain cDNA libraries, and their nucleotide sequence was determined. The isolated cDNA clones represent the entire coding sequence for the rat brain AP50. They encode a polypeptide containing 435 amino acids with a molecular weight of 49,612 daltons. Comparison with the partially sequenced bovine brain AP50 shows a primary structure that is highly conserved. AP50 does not have detectable sequence similarity with other known kinases or with other proteins of known sequence.

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Year:  1988        PMID： 3148444     DOI： 10.1089/dna.1988.7.663

Source DB:  PubMed          Journal:  DNA        ISSN： 0198-0238


  12 in total

1.  Distinct and redundant functions of mu1 medium chains of the AP-1 clathrin-associated protein complex in the nematode Caenorhabditis elegans.

Authors:  J Shim; P W Sternberg; J Lee
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

2.  Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization.

Authors:  C Guilbaud; M Peyrard; I Fransson; S W Clifton; B A Roe; N P Carter; J P Dumanski
Journal:  Mamm Genome       Date:  1997-09       Impact factor: 2.957

3.  Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant mu2 subunit and its effects on endocytosis.

Authors:  A Nesterov; R E Carter; T Sorkina; G N Gill; A Sorkin
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

4.  Inositol polyphosphate receptor and clathrin assembly protein AP-2 are related proteins that form potassium-selective ion channels in planar lipid bilayers.

Authors:  A P Timerman; M M Mayrleitner; T J Lukas; C C Chadwick; A Saito; D M Watterson; H Schindler; S Fleischer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

5.  Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.

Authors:  I Rapoport; M Miyazaki; W Boll; B Duckworth; L C Cantley; S Shoelson; T Kirchhausen
Journal:  EMBO J       Date:  1997-05-01       Impact factor: 11.598

6.  Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.

Authors:  T Kirchhausen; K L Nathanson; W Matsui; A Vaisberg; E P Chow; C Burne; J H Keen; A E Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

7.  The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin.

Authors:  A M Phillips; M Smith; M Ramaswami; L E Kelly
Journal:  J Neurosci       Date:  2000-11-15       Impact factor: 6.167

8.  The 50 kDa protein subunit of assembly polypeptide (AP) AP-2 adaptor from clathrin-coated vesicles is phosphorylated on threonine-156 by AP-1 and a soluble AP50 kinase which co-purifies with the assembly polypeptides.

Authors:  A Pauloin; C Thurieau
Journal:  Biochem J       Date:  1993-12-01       Impact factor: 3.857

Review 9.  Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface.

Authors:  Joseph Jose Thottacherry; Mugdha Sathe; Chaitra Prabhakara; Satyajit Mayor
Journal:  Annu Rev Cell Dev Biol       Date:  2019-07-05       Impact factor: 13.827

10.  The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.

Authors:  H L Phan; J A Finlay; D S Chu; P K Tan; T Kirchhausen; G S Payne
Journal:  EMBO J       Date:  1994-04-01       Impact factor: 11.598
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