Carolina P B Gracitelli1,2, Nubia Vanessa Lima de Faria3, Izabela Almeida3,4, Diego Torres Dias3,4, Julia Maggi Vieira5, Syril Dorairaj6, Fabio Nishimura Kanadani7, Tiago Santos Prata3,4,6,8. 1. Glaucoma Division, Department of Ophthalmology and Visual Science, Federal University of São Paulo, São Paulo, Brazil, carolepm@gmail.com. 2. Glaucoma Division, Ver Mais Oftalmologia, Vinhedo, Brazil, carolepm@gmail.com. 3. Glaucoma Division, Department of Ophthalmology and Visual Science, Federal University of São Paulo, São Paulo, Brazil. 4. Glaucoma Division, Hospital Medicina dos Olhos, Osasco, Brazil. 5. Faculdade de Ciências Médicas de Belo Horizonte, Belo Horizonte, Brazil. 6. Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida, USA. 7. Glaucoma Department, Instituto de Olhos Ciências Médicas, Belo Horizonte, Brazil. 8. Glaucoma Service, Department of Ophthalmology, Hospital Oftalmológico de Sorocaba - BOS, Sorocaba, Brazil.
Abstract
PURPOSE: To evaluate exercise-induced changes in ocular blood flow (OBF) parameters in primary open-angle glaucoma (POAG) patients. METHODS: A prospective observational study was carried out, in which medically treated patients with POAG were enrolled. Following inclusion, all patients performed a 40-min cycloergometry in a standardized fashion. The following parameters were measured and compared immediately before and 1 and 30 min after the exercise: intraocular pressure (IOP; Goldman applanation tonometry), mean arterial pressure (MAP), ocular pulse amplitude (OPA; assessed by dynamic contour tonometry), and ocular perfusion pressure (OPP; 2/3 MAP - IOP). In addition, we investigated possible factors associated with OBF parameter changes immediately after exercise. RESULTS: A total of 30 eyes (30 patients; mean age was 62.9 ± 1.7 years) were included. Most patients were women (53%), and median visual field mean deviation index was -3.5 dB. Both MAP (mean change, 21%) and IOP (mean change, 17.3%) increased significantly immediately after the workout (p < 0.01), persisting higher than baseline following 30 min (p < 0.01%). Regarding OBF parameters, both OPA (mean change, 58.8%) and OPP (mean change, 21.7%) increased significantly immediately after the workout and persisted higher than baseline 30 min after the workout (p < 0.01). Regression analysis revealed that only age was significantly associated with OPA variation (R2 0.14; p < 0.05). No significant associations were found for OPP (p ≥ 0.19). CONCLUSION: Aerobic exercise leads to a significant short-time increase in OBF parameters in patients with POAG. Even though IOP seems to present a modest elevation, it is accompanied by a significant increase in MAP, leading to higher OBF measurements. Exercise-induced short-term changes and its possible implications for glaucoma prognosis deserve further investigation.
PURPOSE: To evaluate exercise-induced changes in ocular blood flow (OBF) parameters in primary open-angle glaucoma (POAG) patients. METHODS: A prospective observational study was carried out, in which medically treated patients with POAG were enrolled. Following inclusion, all patients performed a 40-min cycloergometry in a standardized fashion. The following parameters were measured and compared immediately before and 1 and 30 min after the exercise: intraocular pressure (IOP; Goldman applanation tonometry), mean arterial pressure (MAP), ocular pulse amplitude (OPA; assessed by dynamic contour tonometry), and ocular perfusion pressure (OPP; 2/3 MAP - IOP). In addition, we investigated possible factors associated with OBF parameter changes immediately after exercise. RESULTS: A total of 30 eyes (30 patients; mean age was 62.9 ± 1.7 years) were included. Most patients were women (53%), and median visual field mean deviation index was -3.5 dB. Both MAP (mean change, 21%) and IOP (mean change, 17.3%) increased significantly immediately after the workout (p < 0.01), persisting higher than baseline following 30 min (p < 0.01%). Regarding OBF parameters, both OPA (mean change, 58.8%) and OPP (mean change, 21.7%) increased significantly immediately after the workout and persisted higher than baseline 30 min after the workout (p < 0.01). Regression analysis revealed that only age was significantly associated with OPA variation (R2 0.14; p < 0.05). No significant associations were found for OPP (p ≥ 0.19). CONCLUSION: Aerobic exercise leads to a significant short-time increase in OBF parameters in patients with POAG. Even though IOP seems to present a modest elevation, it is accompanied by a significant increase in MAP, leading to higher OBF measurements. Exercise-induced short-term changes and its possible implications for glaucoma prognosis deserve further investigation.
Authors: Teresa Zwierko; Wojciech Jedziniak; Beata Florkiewicz; Piotr Lesiakowski; Marta Śliwiak; Marta Kirkiewicz; Wojciech Lubiński Journal: Int J Environ Res Public Health Date: 2022-02-03 Impact factor: 3.390