Two Hands Grip Better Than One for Tight Binding and Specificity: How a Phage Endolysin Fits into the Cell Wall of Its Host.

Endolysin enzymes of bacteriophages that cut up cell walls have a potential use in combating bacterial antibiotic resistance. In this issue of Structure, Lee et al. (2019) present tandem SH3b domains as the structural basis of an endolysin against Bacillus cereus that selectively recognize opposing glycan strands of the bacterial cell wall peptidoglycan.