| Literature DB >> 31483926 |
Barry M Trost1, Zhiwei Jiao1, Chao-I Joey Hung1.
Abstract
A general method for asymmetric synthesis of heteroaryl-containing cycles via palladium-catalyzed cyclization is reported. Most classes of nitrogen-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo[4.3.1]decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.Entities:
Keywords: asymmetric catalysis; cycloadditions; heterocycles; palladium; trimethylenemethane
Year: 2019 PMID： 31483926 DOI： 10.1002/anie.201910061
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336