Ute Scheller1, Roxanne Lofredi1, Bernadette C M van Wijk1,2,3, Assel Saryyeva4, Joachim K Krauss4, Gerd-Helge Schneider5, Daniel Kroneberg1, Patricia Krause1, Wolf-Julian Neumann1, Andrea A Kühn1,6. 1. Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany. 2. Integrative Model-Based Cognitive Neuroscience Research Unit, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands. 3. Wellcome Centre for Human Neuroimaging, University College London Institute of Neurology, London, UK. 4. Medizinische Hochschule Hannover, Department of Neurosurgery, Hannover, Germany. 5. Charité, Universitätsmedizin Berlin, Campus Mitte, Department of Neurosurgery, Berlin, Germany. 6. NeuroCure, Universitätsmedizin Berlin, Berlin, Germany.
Abstract
OBJECTIVE: This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months. METHODS: Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1-T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3-12 Hz) and beta range (13-30 Hz). RESULTS: A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3-12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3-7.5), but not beta activity (13-30 Hz) was revealed within participants across timepoints. CONCLUSION: Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation.
OBJECTIVE: This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months. METHODS: Local field potentials were recorded in 9 dystoniapatients at 5 timepoints (T1-T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3-12 Hz) and beta range (13-30 Hz). RESULTS: A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3-12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3-7.5), but not beta activity (13-30 Hz) was revealed within participants across timepoints. CONCLUSION: Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation.
Authors: Daniel Sirica; Angela L Hewitt; Christopher G Tarolli; Miriam T Weber; Carol Zimmerman; Aida Santiago; Andrew Wensel; Jonathan W Mink; Karlo J Lizárraga Journal: Neurodegener Dis Manag Date: 2021-07-15