Anna Klinge1, Dalia Khalil2, Björn Klinge2,3,4, Bodil Lund5,6,7, Aron Naimi-Akbar4,5, Sofia Tranaeus4,8, Margareta Hultin2. 1. Department of Oral and Maxillofacial Surgery and Oral Medicine, Malmö University, Malmö, Sweden. 2. Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, Stockholm, Sweden. 3. Department of Periodontology, Malmö University, Malmö, Sweden. 4. Health Technology Assessment-Odontology (HTA-O), Malmö University, Malmö, Sweden. 5. Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden. 6. Department of Clinical Dentistry, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway. 7. Department of Oral and Maxillofacial Surgery, Haukeland University Hospital, Bergen, Norway. 8. Department of Dental Medicine, Division of Cariology, Karolinska Institutet, Stockholm, Sweden.
Abstract
Background: The objective of the study was to assess the effect of prophylactic antibiotics on the outcome of bone augmentation and subsequent dental implant placement by combining the recommended quality assessment methods for systematic reviews and primary studies.Materials and methods: This is a complex systematic review in which systematic reviews as well as primary studies are scrutinised. A search of Medline (OVID), The Cochrane Library (Wiley) and EMBASE, PubMed and Health technology assessment (HTA) organisations as-well as a complementary hand-search was carried out. Selected primary studies were assessed using GRADE. Each study was reviewed by three authors independently. Results: Abstract screening yielded six potential systematic reviews allocated for full-text inspection. A total of ten primary studies were read in full-text. No relevant systematic reviews regarding the topic of this article were found. The quality assessment resulted in two primary studies with a moderate risk of bias. Of the two studies with a moderate risk of bias, one compared a single dose of clindamycin 600 mg preoperatively with the same preoperative dose followed by four doses of 300 mg every 6 h. The second study compared a single dose prophylaxis of two different types of antibiotic compounds. Conclusion: In conclusion, the scientific evidence regarding the use of antibiotic prophylaxis for reducing the risk of infection in conjunction with bone augmentation procedures during dental implant placement is very limited. The infection rate as compared to nonusage of prophylactic antibiotics, selection of the most suitable compound, and the optimal duration of prophylactic treatment is still unknown.
Background: The objective of the study was to assess the effect of prophylactic antibiotics on the outcome of bone augmentation and subsequent dental implant placement by combining the recommended quality assessment methods for systematic reviews and primary studies.Materials and methods: This is a complex systematic review in which systematic reviews as well as primary studies are scrutinised. A search of Medline (OVID), The Cochrane Library (Wiley) and EMBASE, PubMed and Health technology assessment (HTA) organisations as-well as a complementary hand-search was carried out. Selected primary studies were assessed using GRADE. Each study was reviewed by three authors independently. Results: Abstract screening yielded six potential systematic reviews allocated for full-text inspection. A total of ten primary studies were read in full-text. No relevant systematic reviews regarding the topic of this article were found. The quality assessment resulted in two primary studies with a moderate risk of bias. Of the two studies with a moderate risk of bias, one compared a single dose of clindamycin 600 mg preoperatively with the same preoperative dose followed by four doses of 300 mg every 6 h. The second study compared a single dose prophylaxis of two different types of antibiotic compounds. Conclusion: In conclusion, the scientific evidence regarding the use of antibiotic prophylaxis for reducing the risk of infection in conjunction with bone augmentation procedures during dental implant placement is very limited. The infection rate as compared to nonusage of prophylactic antibiotics, selection of the most suitable compound, and the optimal duration of prophylactic treatment is still unknown.
Entities:
Keywords:
Antibiotic prophylaxis; bone transplantation; dental implants; systematic review
Authors: Khalid T Aboalshamat; Assim M Banjar; Mahmoud I Al-Jaber; Noor M Turkistani; Mohammed T Al-Amoudi Journal: Open Access Maced J Med Sci Date: 2019-08-10
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