Literature DB >> 31483106

Using Evans Blue Dye to Determine Blood-Brain Barrier Integrity in Rodents.

Mariana Pereira de Souza Goldim1, Amanda Della Giustina1, Fabricia Petronilho1.   

Abstract

The blood-brain barrier (BBB) is an active and selective barrier that shields the brain from endogenous and exogenous insults. Different stimuli may lead to the disruption of this barrier, including inflammation and trauma. Several methods are used to evaluate BBB disruption. The most widely used method is Evans blue (EB) dye extravasation. EB cannot normally pass through the BBB and thus its presence in brain tissue indicates alterations in permeability. This protocol details the steps of EB extravasation in rodents. Important aspects regarding critical steps and advantages are also provided.
© 2019 by John Wiley & Sons, Inc. © 2019 John Wiley & Sons, Inc.

Entities:  

Keywords:  Evans blue; blood-brain barrier; brain

Mesh：

Substances：

Year:  2019        PMID： 31483106     DOI： 10.1002/cpim.83

Source DB:  PubMed          Journal:  Curr Protoc Immunol        ISSN： 1934-3671


  24 in total

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7.  Multimodality molecular imaging of the alveolar-capillary barrier in lung disease using albumin based optical and PET tracers.

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Journal:  Mol Biomed       Date:  2020-12-20

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