Pedro Acosta-Manzano1,2, Francisco M Acosta2,3, Pedro Femia4, Irene Coll-Risco2,5, Víctor Segura-Jiménez6,7, Javier Díaz-Castro5, Julio J Ochoa-Herrera5, Mireille N M Van Poppel8, Virginia A Aparicio2,5. 1. Department of Physical Education and Sports, Faculty of Sport Sciences, PA-HELP "Physical Activity for Health Promotion, CTS-1018" Research group, University of Granada, Granada, Spain. 2. Sport and Health University Research Institute (IMUDS), University of Granada, Granada, Spain. 3. Department of Physical Education and Sports, Faculty of Sport Sciences, PROFITH "PROmoting FITness and Health through Physical Activity" research group, University of Granada, Granada, Spain. 4. Unit of Biostatistics, Department of Statistics and OR, Faculty of Medicine, University of Granada, Granada, Spain. 5. Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology, University of Granada, Granada, Spain. 6. Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain. 7. Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital University of Cádiz, Cádiz, Spain. 8. Institute of Sport Science, University of Graz, Graz, Austria.
Abstract
OBJECTIVES: To analyze the association of sedentary time and physical activity (PA) intensity levels with immunometabolic markers during early pregnancy; and to examine if meeting the PA recommendations is associated with the immunometabolic profile of pregnant women. METHODS: Fifty Caucasian pregnant women (age: 32.8 ± 4.7 years old, body mass index: 24.2 ± 4.1kg/m2 , gestational age: 17 ± 1.5weeks) participated in this cross-sectional study (from September 2015 through May 2016). Sedentary time and PA intensity levels were objectively measured with triaxial accelerometer (seven consecutive valid days). Fasting serum glucose, total cholesterol, phospholipids, and triglycerides were assessed with standard methods. Serum pro-inflammatory and anti-inflammatory cytokines (fractalkine, interleukin-1β, interleukin-6, interleukin-8, interleukin-10, interferon-γ, and tumor necrosis factor-α) were measured using Luminex xMAP technology. RESULTS: Sedentary time and PA were not correlated with any glycemic or lipid marker (P > .05). After adjusting for the potential confounders, vigorous PA showed a positive non-significant association with interleukin-6 (P = .06), and bouts of moderate-vigorous PA was inversely associated with interleukin-1β and interferon-γ (P = .02 and P = .04, respectively). Meeting the PA guidelines was inversely associated with interleukin-1β and positively associated with interleukin-8 (P = .01 and P = .04, respectively). These associations disappeared after controlling for multiplicity. CONCLUSIONS: Increasing the time spent in moderate-vigorous PA, or meeting the PA recommendations, is associated with the cytokine profile of women without metabolic disruptions in early pregnancy. However, sedentary time and PA do not seem to be associated with glucose or lipid levels. These results should be interpreted cautiously in view of the discrepancies after adjusting for multiple comparisons. Future studies in this novel field of research are warranted before reaching any conclusion.
OBJECTIVES: To analyze the association of sedentary time and physical activity (PA) intensity levels with immunometabolic markers during early pregnancy; and to examine if meeting the PA recommendations is associated with the immunometabolic profile of pregnant women. METHODS: Fifty Caucasian pregnant women (age: 32.8 ± 4.7 years old, body mass index: 24.2 ± 4.1kg/m2 , gestational age: 17 ± 1.5weeks) participated in this cross-sectional study (from September 2015 through May 2016). Sedentary time and PA intensity levels were objectively measured with triaxial accelerometer (seven consecutive valid days). Fasting serum glucose, total cholesterol, phospholipids, and triglycerides were assessed with standard methods. Serum pro-inflammatory and anti-inflammatory cytokines (fractalkine, interleukin-1β, interleukin-6, interleukin-8, interleukin-10, interferon-γ, and tumor necrosis factor-α) were measured using Luminex xMAP technology. RESULTS: Sedentary time and PA were not correlated with any glycemic or lipid marker (P > .05). After adjusting for the potential confounders, vigorous PA showed a positive non-significant association with interleukin-6 (P = .06), and bouts of moderate-vigorous PA was inversely associated with interleukin-1β and interferon-γ (P = .02 and P = .04, respectively). Meeting the PA guidelines was inversely associated with interleukin-1β and positively associated with interleukin-8 (P = .01 and P = .04, respectively). These associations disappeared after controlling for multiplicity. CONCLUSIONS: Increasing the time spent in moderate-vigorous PA, or meeting the PA recommendations, is associated with the cytokine profile of women without metabolic disruptions in early pregnancy. However, sedentary time and PA do not seem to be associated with glucose or lipid levels. These results should be interpreted cautiously in view of the discrepancies after adjusting for multiple comparisons. Future studies in this novel field of research are warranted before reaching any conclusion.
Authors: Pedro Acosta-Manzano; Irene Coll-Risco; Mireille N M Van Poppel; Víctor Segura-Jiménez; Pedro Femia; Lidia Romero-Gallardo; Milkana Borges-Cosic; Javier Díaz-Castro; Jorge Moreno-Fernández; Julio J Ochoa-Herrera; Virginia A Aparicio Journal: J Clin Med Date: 2019-11-03 Impact factor: 4.241
Authors: Adeline Bockler; Nina Ferrari; Clara Deibert; Anne Flöck; Waltraut M Merz; Ulrich Gembruch; Christina Ehrhardt; Jörg Dötsch; Christine Joisten Journal: Int J Environ Res Public Health Date: 2021-12-14 Impact factor: 3.390