Xue Jiao1, Meng-Di Fu1, Ya-Yun Wang2, Jiang Xue2, Yuan Zhang3,4. 1. School of Medicine, Shandong University, Jinan, China. 2. Department of Neonatology, Second Hospital of Shandong University, 247# Beiyuan Road, Jinan, China. 3. Center of Evidence-Based Medicine, Institute of Medical Sciences, Second Hospital of Shandong University, 247# Beiyuan Road, Jinan, China. ebmzhangyuan@yeah.net. 4. School of Public Health, Shandong University, Jinan, China. ebmzhangyuan@yeah.net.
Abstract
BACKGROUND: The therapeutic effect of Bifidobacterium and Lactobacillus on necrotizing enterocolitis (NEC) in very-low-birth-weight preterm infants was controversial, and we aimed to explore the exact impact of the two probiotics. METHODS: The PubMed, EMBASE, Web of Science and Cochrane Library were systematically searched for studies published from January 1, 2010 to February 28, 2019. Results were combined with fixed-effect model or random-effect model with specific conditions. Sensitivity analysis was conducted by the trim-and-fill method, and the Begger's and Egger's test were used to measure publication bias. RESULTS: The meta-analysis included 16 original articles with 4632 very-low-birth-weight preterm infants. With respect to the intervention of Bifidobacterium, we estimated non-significant decrease in the morbidity of NEC with a risk ratio (RR) of 0.75 [95% confidence internal (CI) 0.56-1.01, P = 0.06]. Regarding the effect of Lactobacillus, there was no evidence of significant lower risk in the incidence of NEC (RR = 0.67, 95% CI 0.39-1.17, P = 0.16). The use of mixture of probiotics (Bifidobacterium and Lactobacillus) reduced the risk of NEC in the probiotics group (RR = 0.45, 95% CI 0.25-0.80, P = 0.007). CONCLUSION: The mixture of Bifidobacterium and Lactobacillus could prevent the morbidity of NEC in very-low-birth-weight preterm infants. But Bifidobacterium or Lactobacillus alone did not show this effect.
BACKGROUND: The therapeutic effect of Bifidobacterium and Lactobacillus on necrotizing enterocolitis (NEC) in very-low-birth-weight preterm infants was controversial, and we aimed to explore the exact impact of the two probiotics. METHODS: The PubMed, EMBASE, Web of Science and Cochrane Library were systematically searched for studies published from January 1, 2010 to February 28, 2019. Results were combined with fixed-effect model or random-effect model with specific conditions. Sensitivity analysis was conducted by the trim-and-fill method, and the Begger's and Egger's test were used to measure publication bias. RESULTS: The meta-analysis included 16 original articles with 4632 very-low-birth-weight preterm infants. With respect to the intervention of Bifidobacterium, we estimated non-significant decrease in the morbidity of NEC with a risk ratio (RR) of 0.75 [95% confidence internal (CI) 0.56-1.01, P = 0.06]. Regarding the effect of Lactobacillus, there was no evidence of significant lower risk in the incidence of NEC (RR = 0.67, 95% CI 0.39-1.17, P = 0.16). The use of mixture of probiotics (Bifidobacterium and Lactobacillus) reduced the risk of NEC in the probiotics group (RR = 0.45, 95% CI 0.25-0.80, P = 0.007). CONCLUSION: The mixture of Bifidobacterium and Lactobacillus could prevent the morbidity of NEC in very-low-birth-weight preterm infants. But Bifidobacterium or Lactobacillus alone did not show this effect.
Authors: Kathleen Sim; Alexander G Shaw; Paul Randell; Michael J Cox; Zoë E McClure; Ming-Shi Li; Munther Haddad; Paul R Langford; William O C M Cookson; Miriam F Moffatt; J Simon Kroll Journal: Clin Infect Dis Date: 2014-10-23 Impact factor: 9.079
Authors: Arianna Aceti; Davide Gori; Giovanni Barone; Maria Luisa Callegari; Antonio Di Mauro; Maria Pia Fantini; Flavia Indrio; Luca Maggio; Fabio Meneghin; Lorenzo Morelli; Gianvincenzo Zuccotti; Luigi Corvaglia Journal: Ital J Pediatr Date: 2015-11-14 Impact factor: 2.638