Nathalie E Holz1, Andreas Meyer-Lindenberg2. 1. Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters, Zentralinstitut für seelische Gesundheit, Medizinische Fakultät Mannheim (Universität Heidelberg), J5, 68167, Mannheim, Deutschland. nathalie.holz@zi-mannheim.de. 2. Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters, Zentralinstitut für seelische Gesundheit, Medizinische Fakultät Mannheim (Universität Heidelberg), J5, 68167, Mannheim, Deutschland.
Abstract
BACKGROUND: The social brain is dysfunctional in numerous stress-related psychiatric disorders. OBJECTIVE: The definition of social brain networks and their susceptibility for social environmental stress. It is also reviewed how social brain networks are disrupted in schizophrenia, autism and conduct disorder. MATERIAL AND METHODS: Literature search in PubMed. RESULTS: The social brain consists of several subnetworks that act in concert to foster empathy. Interestingly, except for the mirror neuron system, the neural networks of the social brain have been reported to be vulnerable to social environmental stress and have also been highlighted as being compromised in psychiatric disorders. As an example, schizophrenia is related to dysfunction in social perception, mentalizing, and affiliation, whereas the most pronounced deficits in autism are seen during social perception and mentalizing. Patients with conduct disorder are more prone to dysfunction in perception, affiliation and aversion. CONCLUSION: Social stress affects subnetworks also compromised in psychiatric disorders. Therefore, it is plausible that the social brain might mediate the association between social stress and psychiatric disorders. To advance ecological validity in social neuroscience, recent research has highlighted the role of hyperscanning and virtual reality as means by which a more naturalistic assessment of social interactions might be feasible.
BACKGROUND: The social brain is dysfunctional in numerous stress-related psychiatric disorders. OBJECTIVE: The definition of social brain networks and their susceptibility for social environmental stress. It is also reviewed how social brain networks are disrupted in schizophrenia, autism and conduct disorder. MATERIAL AND METHODS: Literature search in PubMed. RESULTS: The social brain consists of several subnetworks that act in concert to foster empathy. Interestingly, except for the mirror neuron system, the neural networks of the social brain have been reported to be vulnerable to social environmental stress and have also been highlighted as being compromised in psychiatric disorders. As an example, schizophrenia is related to dysfunction in social perception, mentalizing, and affiliation, whereas the most pronounced deficits in autism are seen during social perception and mentalizing. Patients with conduct disorder are more prone to dysfunction in perception, affiliation and aversion. CONCLUSION: Social stress affects subnetworks also compromised in psychiatric disorders. Therefore, it is plausible that the social brain might mediate the association between social stress and psychiatric disorders. To advance ecological validity in social neuroscience, recent research has highlighted the role of hyperscanning and virtual reality as means by which a more naturalistic assessment of social interactions might be feasible.
Entities:
Keywords:
Autism; Conduct disorder; Schizophrenia; Social brain; Social stress
Authors: Mitul A Mehta; Emma Gore-Langton; Nicole Golembo; Emma Colvert; Steven C R Williams; Edmund Sonuga-Barke Journal: J Cogn Neurosci Date: 2010-10 Impact factor: 3.225
Authors: Patrick Zimmer; Benjamin Buttlar; Georg Halbeisen; Eva Walther; Gregor Domes Journal: Psychoneuroendocrinology Date: 2018-11-10 Impact factor: 4.905
Authors: Nathalie E Holz; Regina Boecker-Schlier; Arlette F Buchmann; Dorothea Blomeyer; Christine Jennen-Steinmetz; Sarah Baumeister; Michael M Plichta; Anna Cattrell; Gunter Schumann; Günter Esser; Martin Schmidt; Jan Buitelaar; Andreas Meyer-Lindenberg; Tobias Banaschewski; Daniel Brandeis; Manfred Laucht Journal: Soc Cogn Affect Neurosci Date: 2017-02-01 Impact factor: 3.436