Literature DB >> 3148185

[Spinal mechanism of the antispastic action of TRH in patients with amyotrophic lateral sclerosis].

C Morin1, E Pierrot-Deseilligny.   

Abstract

Effects of high-dose TRH on the vibratory inhibition of soleus H-reflex have been studied in 9 patients with amyotrophic lateral sclerosis. In 6 of the 9, TRH induced a significant increase in vibratory inhibition. This suggests that the TRH-induced reduction of spasticity might be due to an increase in presynaptic inhibition acting on Ia fibres.

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Year:  1988        PMID: 3148185

Source DB:  PubMed          Journal:  Rev Neurol (Paris)        ISSN: 0035-3787            Impact factor:   2.607


  2 in total

1.  Evidence for presynaptic inhibition on trigeminal primary afferent fibres in humans.

Authors:  A Rossi; C Scarpini
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-04       Impact factor: 10.154

2.  Impaired stretch reflex and joint torque modulation during spastic gait in multiple sclerosis patients.

Authors:  T Sinkjaer; J B Andersen; J F Nielsen
Journal:  J Neurol       Date:  1996-08       Impact factor: 4.849

  2 in total

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