Burcin Uygun1, Sinem Kiyici2, Suay Ozmen3, Zulfiye Gul4, Deniz Sigirli5, Sinan Cavun6. 1. Department of Internal Medicine, Bursa Yuksek Ihtisas Education and Training Hospital, University of Health Sciences, Bursa, Turkey. 2. Department of Endocrinology and Metabolism, Bursa Yuksek Ihtisas Education and Training Hospital, University of Health Sciences, Bursa, Turkey. 3. Department of Otorhinolaryngology, Bursa Yuksek Ihtisas Education and Training Hospital, University of Health Sciences, Bursa, Turkey. 4. Department of Pharmacology, Medical Faculty, Bahcesehir University, Istanbul, Turkey. 5. Department of Bio-Statistics, Medical Faculty, Uludag University, Bursa, Turkey. 6. Department of Pharmacology, Medical Faculty, Uludag University, Bursa, Turkey.
Abstract
Purpose: To investigate the olfaction and taste functions in obese female patients and the association between serum ghrelin and leptin levels compared with healthy controls. Methods: Fifty-two obese women, who have a body mass index >30 kg/m2, and 15 healthy women were included in the study. After 8 hrs fasting, blood samples were taken for serum biochemical parameters, ghrelin, and leptin level measurement. For the quantitative assessment of olfactory function, all participants underwent an N-butanol threshold test and odor identification test using 12 Sniffin' Sticks® fragrance sticks. The gustatory function was tested by administering a whole-mouth above threshold test using sucrose solutions. Results: The sucrose taste threshold score in obese women was significantly higher than the controls (P = 0.004). We found positively significant correlation between serum ghrelin levels and n-butanol threshold scores in obese women (r = 0.300, P = 0.031). N-butanol smell threshold was not significantly different between the two groups (P = 0.149), while the Sniffin' Sticks smell test scores were significantly lower in obese women compared with the controls (P = 0.007). Serum leptin levels were also significantly higher in obese women (P < 0.001) although there was no significant difference in serum ghrelin levels between the two groups (P = 0.768). There was no correlation between serum leptin levels and Sniffin' Sticks scores, n-butanol, and sucrose taste threshold scores in obese women. Conclusions: These results might suggest that leptin, which is an anorexigenic peptide, may have a negative effect on taste and smell functions. More studies are warranted to elucidate the exact role of ghrelin secretion on olfaction and taste functions.
Purpose: To investigate the olfaction and taste functions in obese female patients and the association between serum ghrelin and leptin levels compared with healthy controls. Methods: Fifty-two obesewomen, who have a body mass index >30 kg/m2, and 15 healthy women were included in the study. After 8 hrs fasting, blood samples were taken for serum biochemical parameters, ghrelin, and leptin level measurement. For the quantitative assessment of olfactory function, all participants underwent an N-butanol threshold test and odor identification test using 12 Sniffin' Sticks® fragrance sticks. The gustatory function was tested by administering a whole-mouth above threshold test using sucrose solutions. Results: The sucrose taste threshold score in obesewomen was significantly higher than the controls (P = 0.004). We found positively significant correlation between serum ghrelin levels and n-butanol threshold scores in obesewomen (r = 0.300, P = 0.031). N-butanol smell threshold was not significantly different between the two groups (P = 0.149), while the Sniffin' Sticks smell test scores were significantly lower in obesewomen compared with the controls (P = 0.007). Serum leptin levels were also significantly higher in obesewomen (P < 0.001) although there was no significant difference in serum ghrelin levels between the two groups (P = 0.768). There was no correlation between serum leptin levels and Sniffin' Sticks scores, n-butanol, and sucrose taste threshold scores in obesewomen. Conclusions: These results might suggest that leptin, which is an anorexigenic peptide, may have a negative effect on taste and smell functions. More studies are warranted to elucidate the exact role of ghrelin secretion on olfaction and taste functions.
Authors: Gerold Besser; Brigitte Erlacher; Kadriye Aydinkoc-Tuzcu; David T Liu; Eleonore Pablik; Verena Niebauer; Martin Koenighofer; Bertold Renner; Christian A Mueller Journal: J Clin Med Date: 2020-01-29 Impact factor: 4.241
Authors: Daniela Staníková; Lea Krajčovičová; Linda Demková; Petronela Forišek-Paulová; Lucia Slobodová; Eva Vitariušová; Lubica Tichá; Barbara Ukropcová; Juraj Staník; Jozef Ukropec Journal: Front Psychiatry Date: 2022-07-22 Impact factor: 5.435