PURPOSE: To characterize retinal capillary complexity by optical coherence tomography angiography in Parkinson disease. METHOD: Twenty-five Parkinson disease patients and 25 age- and gender-matched healthy controls were recruited. Optical coherence tomography angiography and optical coherence tomography imaged the superficial and deep retinal capillary plexuses and retinal structure. Retinal capillary skeleton density, retinal capillary perfusion density, and fractal dimension analysis of retinal capillary complexity were performed in the total annular zone and quadrant sectors. The thickness of retinal nerve fiber layer, ganglion cell layer and inner plexiform layer, and total retinal thickness were extracted from retinal structural images. Relationships among the retinal capillaries, retinal structure, and clinical parameters were analyzed. RESULTS: The superficial retinal capillary plexus in Parkinson disease patients had lower retinal capillary skeleton and perfusion densities and capillary complexity in the total annular zone and all quadrant sectors compared with healthy control subjects. The deep retinal capillary plexus retinal capillary complexity was decreased in the total annular zone and the superior and inferior quadrants. The retinal capillary complexity in the inferior quadrant was negatively correlated with the best-corrected visual acuity and disease duration (r = -0.61, r = -0.43, respectively, both P < 0.05). CONCLUSION: As determined by fractal analysis, retinal capillary complexity can be an objective biomarker in Parkinson disease.
PURPOSE: To characterize retinal capillary complexity by optical coherence tomography angiography in Parkinson disease. METHOD: Twenty-five Parkinson diseasepatients and 25 age- and gender-matched healthy controls were recruited. Optical coherence tomography angiography and optical coherence tomography imaged the superficial and deep retinal capillary plexuses and retinal structure. Retinal capillary skeleton density, retinal capillary perfusion density, and fractal dimension analysis of retinal capillary complexity were performed in the total annular zone and quadrant sectors. The thickness of retinal nerve fiber layer, ganglion cell layer and inner plexiform layer, and total retinal thickness were extracted from retinal structural images. Relationships among the retinal capillaries, retinal structure, and clinical parameters were analyzed. RESULTS: The superficial retinal capillary plexus in Parkinson diseasepatients had lower retinal capillary skeleton and perfusion densities and capillary complexity in the total annular zone and all quadrant sectors compared with healthy control subjects. The deep retinal capillary plexus retinal capillary complexity was decreased in the total annular zone and the superior and inferior quadrants. The retinal capillary complexity in the inferior quadrant was negatively correlated with the best-corrected visual acuity and disease duration (r = -0.61, r = -0.43, respectively, both P < 0.05). CONCLUSION: As determined by fractal analysis, retinal capillary complexity can be an objective biomarker in Parkinson disease.
Authors: Ane Murueta-Goyena; Rocío Del Pino; Marta Galdós; Begoña Arana; Marian Acera; Mar Carmona-Abellán; Tamara Fernández-Valle; Beatriz Tijero; Olaia Lucas-Jiménez; Natalia Ojeda; Naroa Ibarretxe-Bilbao; Javier Peña; Jesus Cortes; Unai Ayala; Maitane Barrenechea; Juan Carlos Gómez-Esteban; Iñigo Gabilondo Journal: Ann Neurol Date: 2020-11-09 Impact factor: 10.422
Authors: Ane Murueta-Goyena; Maitane Barrenechea; Asier Erramuzpe; Sara Teijeira-Portas; Marta Pengo; Unai Ayala; David Romero-Bascones; Marian Acera; Rocío Del Pino; Juan Carlos Gómez-Esteban; Iñigo Gabilondo Journal: Front Neurosci Date: 2021-07-12 Impact factor: 4.677