Christine G Parks1, Jesse Wilkerson2, Kathryn M Rose, Abdullah Faiq3, Payam Noroozi Farhadi3, Craig S Long4, Nastaran Bayat3, Hermine I Brunner5, Bob Goldberg6, John A McGrath2, Frederick W Miller3, Lisa G Rider3. 1. National Institute of Environmental Health Sciences/NIH, Durham, North Carolina. 2. Social Scientific & Systems, Durham, North Carolina. 3. National Institute of Environmental Health Sciences/NIH,, Bethesda, Maryland. 4. National Oceanic and Atmospheric Administration/National Weather Service, National Centers for Environmental Prediction Climate Prediction Center, College Park, Maryland. 5. Cincinnati Children's Medical Center, Cincinnati, Ohio. 6. The Myositis Association, Alexandria, Virginia.
Abstract
OBJECTIVE: Dermatomyositis (DM) has been associated with geospatial differences in ultraviolet (UV) radiation, but the role of individual determinants of UV exposure prior to diagnosis is unknown. The objective was to examine the role of those individual determinants. METHODS: We analyzed questionnaire data from 1,350 adults in a US national myositis registry (638 with DM, 422 with polymyositis [PM], and 290 with inclusion body myositis [IBM] diagnosed at ages 18-65 years), examining the likelihood of DM compared with PM and IBM diagnosis, in relation to self-reported sunburn history and job- and hobby-related sun exposures in the year prior to diagnosis. We estimated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression adjusted for age, skin tone, and sex, to determine the association of individual UV exposures with DM diagnosis. We also evaluated the proportion of DM by maximum daily ambient UV exposure, based on UVB erythemal irradiances for participant residence in the year prior to diagnosis. RESULTS: DM was associated with sunburn in the year before diagnosis (2 or more sunburns OR 1.77 [95% CI 1.28-2.43] versus PM/IBM; 1 sunburn OR 1.44 [95% CI 1.06-1.95]) and with having elevated job- or hobby-related sun exposure (high exposure OR 1.64 [95% CI 1.08-2.49] or moderate exposure OR 1.35 [95% CI 1.02-1.78] versus low or no exposure). Ambient UV intensity was associated with DM in females (β = 3.97, P = 0.046), but not overall. CONCLUSION: Our findings suggest that high or moderate personal exposure to intense sunlight is associated with developing DM compared with other types of myositis. Prospective research on UV exposure as a modifiable risk factor for DM is warranted.
OBJECTIVE: Dermatomyositis (DM) has been associated with geospatial differences in ultraviolet (UV) radiation, but the role of individual determinants of UV exposure prior to diagnosis is unknown. The objective was to examine the role of those individual determinants. METHODS: We analyzed questionnaire data from 1,350 adults in a US national myositis registry (638 with DM, 422 with polymyositis [PM], and 290 with inclusion body myositis [IBM] diagnosed at ages 18-65 years), examining the likelihood of DM compared with PM and IBM diagnosis, in relation to self-reported sunburn history and job- and hobby-related sun exposures in the year prior to diagnosis. We estimated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression adjusted for age, skin tone, and sex, to determine the association of individual UV exposures with DM diagnosis. We also evaluated the proportion of DM by maximum daily ambient UV exposure, based on UVB erythemal irradiances for participant residence in the year prior to diagnosis. RESULTS: DM was associated with sunburn in the year before diagnosis (2 or more sunburns OR 1.77 [95% CI 1.28-2.43] versus PM/IBM; 1 sunburn OR 1.44 [95% CI 1.06-1.95]) and with having elevated job- or hobby-related sun exposure (high exposure OR 1.64 [95% CI 1.08-2.49] or moderate exposure OR 1.35 [95% CI 1.02-1.78] versus low or no exposure). Ambient UV intensity was associated with DM in females (β = 3.97, P = 0.046), but not overall. CONCLUSION: Our findings suggest that high or moderate personal exposure to intense sunlight is associated with developing DM compared with other types of myositis. Prospective research on UV exposure as a modifiable risk factor for DM is warranted.
Authors: Michal Feldon; Payam Noroozi Farhadi; Hermine I Brunner; Lukasz Itert; Bob Goldberg; Abdullah Faiq; Jesse Wilkerson; Kathryn M Rose; Lisa G Rider; Frederick W Miller; Edward H Giannini Journal: Arthritis Care Res (Hoboken) Date: 2017-09-21 Impact factor: 4.794
Authors: Md M Hossain; Jesse Wilkerson; John A McGrath; Payam N Farhadi; Cole Brokamp; Md T F Khan; Bob Goldberg; Hermine I Brunner; Maurizio Macaluso; Frederick W Miller; Lisa G Rider Journal: Front Med (Lausanne) Date: 2022-03-16
Authors: Christine G Parks; Helen C S Meier; Todd A Jusko; Jesse Wilkerson; Frederick W Miller; Dale P Sandler Journal: Front Immunol Date: 2022-09-13 Impact factor: 8.786