| Literature DB >> 31477828 |
Kunyue Tan1, Yinchuan Lai1, Weijie Chen1, Hang Liu1, Yanping Xu1, Yidan Li1, Hao Zhou1, Wenxin Song2, Jie Wang3, Kamsang Woo4, Yuehui Yin5.
Abstract
Renal denervation (RDN) is a well-known innovative therapy for hypertension. However, the effects of global RDN on blood pressure (BP) lowering are quite variable. Insufficient and futile denervation is considered a major factor contributing to the variable results. Mapping renal nerves by renal nerve stimulation (RNS) is the most promising technique to improve the efficacy of RDN. We summarize the clinical and experimental data available regarding RNS-guided RDN and explain the roles of renal efferent nerves, afferent nerves and vagal nerves in BP changes. We further identify five different BP response patterns to RNS and provide an explanation of the underlying neuroanatomical basis.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31477828 DOI： 10.1038/s41371-019-0244-5
Source DB: PubMed Journal: J Hum Hypertens ISSN： 0950-9240 Impact factor: 3.012