Shunming Zhang1, Jingzhu Fu1, Qing Zhang2, Li Liu2, Min Lu3, Ge Meng1, Zhanxin Yao1,4, Hongmei Wu1, Yang Xia1, Xue Bao1, Yeqing Gu1, Shaomei Sun2, Xing Wang2, Ming Zhou2, Qiyu Jia2, Kun Song2, Yuntang Wu1, Huiling Xiang3, Kaijun Niu5,6. 1. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. 2. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. 3. Department of Gastroenterology, Tianjin Third Central Hospital, Tianjin, China. 4. Tianjin Institute of Health and Environmental Medicine, Tianjin, China. 5. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China. nkj0809@gmail.com. 6. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China. nkj0809@gmail.com.
Abstract
BACKGROUND/ OBJECTIVES: Many studies have suggested that probiotics may be applied as a therapeutic agent for non-alcoholic fatty liver disease (NAFLD). However, the effects of frequent yogurt consumption (as a natural probiotic source) on NAFLD remain poorly understood. This study was to examine the association of habitual yogurt consumption with newly diagnosed NAFLD in the general adult population. SUBJECT/ METHODS: Overall, 24,389 adults were included in this cross-sectional study. Yogurt consumption was estimated by using a validated self-administered food frequency questionnaire. NAFLD was diagnosed by abdominal ultrasonography. We used logistic regression models to assess the association between yogurt consumption categories and newly diagnosed NAFLD. RESULTS: The multivariable odds ratios with 95% confidence interval of newly diagnosed NAFLD were 1.00 (0.88, 1.14) for 1 time/week, 0.91 (0.81, 1.02) for 2-3 times/week, and 0.86 (0.76, 0.98) for ≥4 times/week (P for trend = 0.01), compared with those who consumed <1 time/week yogurt. The inverse association was observed in a sensitivity analysis. CONCLUSION: Higher yogurt consumption was inversely associated with the prevalence of newly diagnosed NAFLD. These results are needed to be confirmed in randomized controlled trials or prospective studies.
BACKGROUND/ OBJECTIVES: Many studies have suggested that probiotics may be applied as a therapeutic agent for non-alcoholic fatty liver disease (NAFLD). However, the effects of frequent yogurt consumption (as a natural probiotic source) on NAFLD remain poorly understood. This study was to examine the association of habitual yogurt consumption with newly diagnosed NAFLD in the general adult population. SUBJECT/ METHODS: Overall, 24,389 adults were included in this cross-sectional study. Yogurt consumption was estimated by using a validated self-administered food frequency questionnaire. NAFLD was diagnosed by abdominal ultrasonography. We used logistic regression models to assess the association between yogurt consumption categories and newly diagnosed NAFLD. RESULTS: The multivariable odds ratios with 95% confidence interval of newly diagnosed NAFLD were 1.00 (0.88, 1.14) for 1 time/week, 0.91 (0.81, 1.02) for 2-3 times/week, and 0.86 (0.76, 0.98) for ≥4 times/week (P for trend = 0.01), compared with those who consumed <1 time/week yogurt. The inverse association was observed in a sensitivity analysis. CONCLUSION: Higher yogurt consumption was inversely associated with the prevalence of newly diagnosed NAFLD. These results are needed to be confirmed in randomized controlled trials or prospective studies.
Authors: Marialena Mouzaki; Elena M Comelli; Bianca M Arendt; Julia Bonengel; Scott K Fung; Sandra E Fischer; Ian D McGilvray; Johane P Allard Journal: Hepatology Date: 2013-05-14 Impact factor: 17.425