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Literature DB >> 3147468

The antiemetic drug trimethobenzamide prevents hypophagia due to acetyl salicylate, but not to 5-HT1B or 5-HT1C agonists.

Abstract

Pretreatment with the antiemetic agent trimethobenzamide (TMB) prevented the hypophagic response of rats to acetyl salicylate (a known emetic in man and dogs). However, it did not affect the hypophagic responses to the 5-HT1B agonist RU24969, or to the 5-HT1C/5-HT1B agonists mCPP and TFMPP. The results therefore suggest that the hypophagic effects of the 5-HT agonists do not involve a malaise-dependent mechanism similar to that mediating the effect of acetyl salicylate.

Entities: Chemical Gene Species

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Year: 1988 PMID： 3147468 DOI： 10.1007/bf02431540

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

14 in total

1. Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat.

Authors: M D Tricklebank; D N Middlemiss; J Neill
Journal: Neuropharmacology Date: 1986-08 Impact factor: 5.250

2. Single administration of 5-HT1A agonists decreases 5-HT1A presynaptic, but not postsynaptic receptor-mediated responses: relationship to antidepressant-like action.

Authors: G A Kennett; M Marcou; C T Dourish; G Curzon
Journal: Eur J Pharmacol Date: 1987-06-12 Impact factor: 4.432

3. 8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance.

Authors: C T Dourish; P H Hutson; G A Kennett; G Curzon
Journal: Appetite Date: 1986 Impact factor: 3.868

4. Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding.

Authors: G J Kilpatrick; B J Jones; M B Tyers
Journal: Nature Date: 1987 Dec 24-31 Impact factor: 49.962

5. Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism.

Authors: W D Miner; G J Sanger
Journal: Br J Pharmacol Date: 1986-07 Impact factor: 8.739

6. The attenuation of a specific cue-to-consequence association by antiemetic agents.

Authors: J D Coil; W G Hankins; D J Jenden; J Garcia
Journal: Psychopharmacology (Berl) Date: 1978-01-31 Impact factor: 4.530

7. Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia.

Authors: P H Hutson; T P Donohoe; G Curzon
Journal: Psychopharmacology (Berl) Date: 1988 Impact factor: 4.530

8. Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors.

Authors: G A Kennett; G Curzon
Journal: Br J Pharmacol Date: 1988-05 Impact factor: 8.739

9. Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats.

Authors: R Samanin; T Mennini; A Ferraris; C Bendotti; F Borsini; S Garattini
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-08 Impact factor: 3.000

10. Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors.

Authors: P H Hutson; C T Dourish; G Curzon
Journal: Eur J Pharmacol Date: 1986-10-07 Impact factor: 4.432

2 in total

1. m-Chlorophenylpiperazine decreases food intake in a test meal.

Authors: A E Walsh; K A Smith; A D Oldman; C Williams; E M Goodall; P J Cowen
Journal: Psychopharmacology (Berl) Date: 1994-09 Impact factor: 4.530

2. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats.

Authors: S J Kitchener; C T Dourish
Journal: Psychopharmacology (Berl) Date: 1994-01 Impact factor: 4.530

2 in total