Literature DB >> 3147465

Modulation of prostacyclin synthetase by cicletanine and drugs which affect ion transport.

C Deby1, R H Bourgain, R Andries, P Braquet.   

Abstract

Cicletanine, a drug which affects membrane ion transport, induces a marked increase of the liberation of PGI2 as demonstrated by the increase of the stable metabolites in the plasma following intravenous administration of arachidonic acid. Furthermore, the inhibiting effect of tranylcypromine on prostacyclin synthetase is completely removed by this pharmacon. These observations are suggestive that this drug presents a scope for treatment of thrombotic disorders as well as hypertension.

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Year:  1988        PMID： 3147465     DOI： 10.1016/s0031-6989(88)80109-7

Source DB:  PubMed          Journal:  Pharmacol Res Commun        ISSN： 0031-6989


  3 in total

1.  Differential effects of prostanoid synthesis inhibitors on cicletanine-induced relaxation of isolated human epigastric arteries.

Authors:  A B Ebeigbe; A Oguogho; A D Ighoroje; C P Aloamaka
Journal:  Clin Auton Res       Date:  1994-06       Impact factor: 4.435

2.  Relationships between kallikrein secretion, kallikrein excretion and beta-adrenoceptors in kidney cortical slices from neurogenic hypertensive dogs.

Authors:  C Damase-Michel; G Bompart; G Durrieu; J L Montastruc; P Montastruc; J P Girolami
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

3.  Cicletanine does not affect plasma atrial natriuretic peptide concentration in healthy subjects.

Authors:  I Berlin; G Deray; G Maistre; F Masson; C Barthelemy; J C Legrand; C Jacobs
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953
  3 in total

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