Liangsuo Ma1,2, Marco Giuseppe Del Buono3,4,5, F Gerard Moeller6,7,8,9. 1. Institute for Drug and Alcohol Studies, Virginia Commonwealth University (VCU), 203 East Cary Street, Suite 202, Richmond, VA, 23219, USA. Liangsuo.ma@vcuhealth.org. 2. Department of Radiology, Virginia Commonwealth University (VCU), 203 East Cary Street, Suite 202, Richmond, VA, 23219, USA. Liangsuo.ma@vcuhealth.org. 3. Pauley Heart Center, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA. 4. C. Kenneth and Dianne and Wright' Center for Clinical and Translational Research, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA. 5. Catholic University of the Sacred Heart, Rome, Italy. 6. Institute for Drug and Alcohol Studies, Virginia Commonwealth University (VCU), 203 East Cary Street, Suite 202, Richmond, VA, 23219, USA. 7. Department of Psychiatry, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA. 8. Department of Pharmacology and Toxicology, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA. 9. Department of Neurology, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA.
Abstract
PURPOSE OF REVIEW: Recently, an association between cannabis use and Takotsubo (stress) cardiomyopathy (TTC) has been shown. With the current trend of legalization of cannabis, it is important to understand brain effects of cannabis use that could lead to cardiac disease, such as TTC. Here we review recent brain imaging studies in order to search for the evidence supporting the association between cannabis use, stress, and TTC. RECENT FINDINGS: There exist brain imaging studies showing similar findings across TTC, stress, and cannabis use. These similar findings are mainly centered on a key central autonomic network region amygdala, i.e., amygdala hyperactivity/hyperconnectivity when exposed to challenge, stress, or negative stimuli. This similarity supports a close association among cannabis use, stress, and TTC. Amygdala-centered neuronal circuits could underlie cannabis use as risk factor to TTC. Based on the findings, several directions for future studies are proposed.
PURPOSE OF REVIEW: Recently, an association between cannabis use and Takotsubo (stress) cardiomyopathy (TTC) has been shown. With the current trend of legalization of cannabis, it is important to understand brain effects of cannabis use that could lead to cardiac disease, such as TTC. Here we review recent brain imaging studies in order to search for the evidence supporting the association between cannabis use, stress, and TTC. RECENT FINDINGS: There exist brain imaging studies showing similar findings across TTC, stress, and cannabis use. These similar findings are mainly centered on a key central autonomic network region amygdala, i.e., amygdala hyperactivity/hyperconnectivity when exposed to challenge, stress, or negative stimuli. This similarity supports a close association among cannabis use, stress, and TTC. Amygdala-centered neuronal circuits could underlie cannabis use as risk factor to TTC. Based on the findings, several directions for future studies are proposed.
Authors: Stephen M Smith; Peter T Fox; Karla L Miller; David C Glahn; P Mickle Fox; Clare E Mackay; Nicola Filippini; Kate E Watkins; Roberto Toro; Angela R Laird; Christian F Beckmann Journal: Proc Natl Acad Sci U S A Date: 2009-07-20 Impact factor: 11.205
Authors: H Donald Burns; Koen Van Laere; Sandra Sanabria-Bohórquez; Terence G Hamill; Guy Bormans; Wai-si Eng; Ray Gibson; Christine Ryan; Brett Connolly; Shil Patel; Stephen Krause; Amy Vanko; Anne Van Hecken; Patrick Dupont; Inge De Lepeleire; Paul Rothenberg; S Aubrey Stoch; Josee Cote; William K Hagmann; James P Jewell; Linus S Lin; Ping Liu; Mark T Goulet; Keith Gottesdiener; John A Wagner; Jan de Hoon; Luc Mortelmans; Tung M Fong; Richard J Hargreaves Journal: Proc Natl Acad Sci U S A Date: 2007-05-29 Impact factor: 11.205
Authors: Krishna Ravindra; Marco G Del Buono; Juan G Chiabrando; Peter Westman; Edoardo Bressi; Dinesh Kadariya; Curtis Maehara; Megan Dell; Liangsuo Ma; Jessie VAN Wezenbeek; F Gerard Moeller; Lori Keyser-Marcus; Larry D Keen; Tamas S Gal; Antonio Abbate Journal: Minerva Cardiol Angiol Date: 2021-01-11
Authors: Liangsuo Ma; John M Hettema; Janna Cousijn; James M Bjork; Joel L Steinberg; Lori Keyser-Marcus; Kyle Woisard; QiQi Lu; Roxann Roberson-Nay; Antonio Abbate; F Gerard Moeller Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2020-10-07