Literature DB >> 31473504

Early childhood lead exposure and the persistence of educational consequences into adolescence.

Ron Shadbegian1, Dennis Guignet2, Heather Klemick3, Linda Bui4.   

Abstract

BACKGROUND: There is consensus that early childhood lead exposure causes adverse cognitive and behavioral effects, even at blood lead levels (BLL) below 5 μg/dL. What has not been established is to what extent the effects of childhood lead exposure persist across grades.
OBJECTIVE: To measure the effects of early childhood lead exposure (BLL 1-10 μg/dL) on educational performance from grades 3-8; to determine if effects in lower grades persist as a child progresses through school; and if so, to characterize the pattern of persistence.
METHODS: We examine data from 560,624 children living in North Carolina between 2000 and 2012 with a BLL ≤10 μg/dL measured between age 0-5 years. Children are matched to their standardized math and reading scores for grades 3-8, creating an unbalanced panel of 2,344,358 student-year observations. We use socio-economic, demographic, and school information along with matching techniques to control for confounding effects.
RESULTS: We find that early childhood exposure to low lead levels caused persistent deficits in educational performance across grades. In each grade (3-8), children with higher blood lead levels had, on average, lower percentile scores in both math and reading than children with lower blood lead levels. In our primary model, we find that children with BLL = 5 μg/dL in early childhood ranked 0.90-1.20 (1.35-1.55) percentiles lower than children with BLL ≤ 1 μg/dL on math (reading) tests during grades 3-8. As children progressed through school, the average percentile deficit in their test scores remained stable.
CONCLUSIONS: Our study shows that the adverse effects of early childhood exposure to low lead levels persist through early adolescence, and that the magnitude of the test-score percentile deficit remains steady between grades 3-8.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Blood lead level; Children; Cognitive development; Education; Lead

Mesh:

Substances:

Year:  2019        PMID: 31473504      PMCID: PMC7038535          DOI: 10.1016/j.envres.2019.108643

Source DB:  PubMed          Journal:  Environ Res        ISSN: 0013-9351            Impact factor:   6.498


  24 in total

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Review 2.  Childhood lead poisoning: the promise and abandonment of primary prevention.

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3.  What grades and achievement tests measure.

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4.  Why are children born to teen mothers at risk for adverse outcomes in young adulthood? Results from a 20-year longitudinal study.

Authors:  S Jaffee; A Caspi; T E Moffitt; J Belsky; P Silva
Journal:  Dev Psychopathol       Date:  2001

5.  The influence of age of lead exposure on adult gray matter volume.

Authors:  Christopher J Brubaker; Kim N Dietrich; Bruce P Lanphear; Kim M Cecil
Journal:  Neurotoxicology       Date:  2010-03-11       Impact factor: 4.294

6.  Moderate lead exposure and elementary school end-of-grade examination performance.

Authors:  Sheryl Magzamen; Pamela Imm; Michael S Amato; Jeffrey A Havlena; Henry A Anderson; Colleen F Moore; Marty S Kanarek
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7.  Environmental contributors to the achievement gap.

Authors:  Marie Lynn Miranda; Dohyeong Kim; Jerome Reiter; M Alicia Overstreet Galeano; Pamela Maxson
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8.  Decreased brain volume in adults with childhood lead exposure.

Authors:  Kim M Cecil; Christopher J Brubaker; Caleb M Adler; Kim N Dietrich; Mekibib Altaye; John C Egelhoff; Stephanie Wessel; Ilayaraja Elangovan; Richard Hornung; Kelly Jarvis; Bruce P Lanphear
Journal:  PLoS Med       Date:  2008-05-27       Impact factor: 11.069

9.  Black-white blood pressure disparities: depressive symptoms and differential vulnerability to blood lead.

Authors:  Margaret T Hicken; Gilbert C Gee; Cathleen Connell; Rachel C Snow; Jeffrey Morenoff; Howard Hu
Journal:  Environ Health Perspect       Date:  2012-10-25       Impact factor: 9.031

10.  The relationship between early childhood blood lead levels and performance on end-of-grade tests.

Authors:  Marie Lynn Miranda; Dohyeong Kim; M Alicia Overstreet Galeano; Christopher J Paul; Andrew P Hull; S Philip Morgan
Journal:  Environ Health Perspect       Date:  2007-08       Impact factor: 9.031

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  3 in total

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2.  Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IP3R-Ca2+-ASK1-p38 signaling pathway.

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3.  Rural and Urban Ecologies of Early Childhood Toxic Lead Exposure: The State of Kansas, 2005 to 2012.

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Journal:  Kans J Med       Date:  2022-08-22
  3 in total

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