Literature DB >> 31472957

Crystal structure of human YTHDC2 YTH domain.

Chao Ma1, Shanhui Liao1, Zhongliang Zhu2.   

Abstract

N6-methyladenosine (m6A) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the m6A readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted m6A RNA. However, how YTH domain of YTHDC2 recognize m6A RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved m6A binding pocket, and similar RNA binding surface shared by YTHDC1.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Crystal structure; YTH domain; YTHDC2; m(6)A RNA

Mesh：

Substances：

Year:  2019        PMID： 31472957     DOI： 10.1016/j.bbrc.2019.08.107

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


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