Rossana Bussani1, Fabio DE-Giorgio2, Giuliano Pesel1, Lorenzo Zandonà1, Gianfranco Sinagra3, Simone Grassi4, Alfonso Baldi5, Antonio Abbate6, Furio Silvestri1. 1. Institute of Pathological Anatomy, Riuniti Hospital and University of Trieste, Trieste, Italy. 2. Institute of Public Health, Section of Legal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy fabio.degiorgio@unicatt.it. 3. Cardiovascular Department, Riuniti Hospital and University of Trieste, Trieste, Italy. 4. Institute of Public Health, Section of Legal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy. 5. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, L. Vanvitelli University of Campania, Caserta, Italy. 6. VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, U.S.A.
Abstract
AIM: We examined evidence on infective and non-infective endocarditis obtained from a database of 50,403 clinical autopsies performed at an Italian general hospital between January 1983 and December 2006. MATERIALS AND METHODS: Out of 814 endocarditis cases, 409 were of infective endocarditis (IE) and 405 non-infective (NIE). The median age at the time of death was 78 years for those with IE and 83 for those with NIE. Data were collected on gender, clinical history, comorbidities, kind of affected valve (non-prosthetic/mechanical/biological), pathological features of endocarditis, endocarditis complications and microbiological agents. RESULTS: The diagnosis of IE was frequently missed and these conditions were often complicated by cardiovascular events. IE was more common among patients with prior valve infection or cardiovascular surgery, while malignancies were frequent comorbidities of NIE. CONCLUSION: In general, we found several data that differ from those generally present in the scientific literature, and this could be explained by the fact that data on IE and NIE are generally obtained from surgical and clinical databases, while we analysed only autoptic cases. Copyright
AIM: We examined evidence on infective and non-infective endocarditis obtained from a database of 50,403 clinical autopsies performed at an Italian general hospital between January 1983 and December 2006. MATERIALS AND METHODS: Out of 814 endocarditis cases, 409 were of infective endocarditis (IE) and 405 non-infective (NIE). The median age at the time of death was 78 years for those with IE and 83 for those with NIE. Data were collected on gender, clinical history, comorbidities, kind of affected valve (non-prosthetic/mechanical/biological), pathological features of endocarditis, endocarditis complications and microbiological agents. RESULTS: The diagnosis of IE was frequently missed and these conditions were often complicated by cardiovascular events. IE was more common among patients with prior valve infection or cardiovascular surgery, while malignancies were frequent comorbidities of NIE. CONCLUSION: In general, we found several data that differ from those generally present in the scientific literature, and this could be explained by the fact that data on IE and NIE are generally obtained from surgical and clinical databases, while we analysed only autoptic cases. Copyright
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