Seong Kwang Lim1, Jean Yoo1, Haewon Kim1, Woong Kim1, Ilseob Shim1, Byung-Il Yoon2, Pilje Kim1, Seung DO Yu1, Ig-Chun Eom3. 1. Environmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea. 2. College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, Republic of Korea. 3. Environmental Health Research Department, National Institute of Environmental Research, Incheon, Republic of Korea iceom@korea.kr.
Abstract
BACKGROUND/AIM: The use of glycolic acid is present in a variety of consumer products, including medicines, cleaners, cosmetics, and paint strippers. It has recently led to concerns about toxicity from inhalation exposure. Herein, the pulmonary toxicity of glycolic acid was investigated in rats. MATERIALS AND METHODS: We conducted acute (~458 mg/m3) and sub-acute (~49.5 mg/m3) inhalation tests to identify the potential toxicities of glycolic acid. RESULTS: Inhalation exposure to glycolic acid in the acute and subacute inhalation tests did not cause any specific changes in clinical examinations, including body weight, organ weight, hematology, serum biochemistry, and histopathology. The polymorphonuclear neutrophils (PMNs) and inflammatory cytokines in Bronchoalveolar lavage fluid (BALF) increased in rats exposed to single and repeated inhalations. In the sub-acute test, the changes induced by glycolic acid were minor or returned to normal during the recovery period. CONCLUSION: The No Observed Adverse Effect Concentration (NOAEC) for the nasal and pulmonary toxicity of glycolic acid was determined to be over 50 mg/m3 at the end of a 28-day inhalation test in male rats. Copyright
BACKGROUND/AIM: The use of glycolic acid is present in a variety of consumer products, including medicines, cleaners, cosmetics, and paint strippers. It has recently led to concerns about toxicity from inhalation exposure. Herein, the pulmonary toxicity of glycolic acid was investigated in rats. MATERIALS AND METHODS: We conducted acute (~458 mg/m3) and sub-acute (~49.5 mg/m3) inhalation tests to identify the potential toxicities of glycolic acid. RESULTS: Inhalation exposure to glycolic acid in the acute and subacute inhalation tests did not cause any specific changes in clinical examinations, including body weight, organ weight, hematology, serum biochemistry, and histopathology. The polymorphonuclear neutrophils (PMNs) and inflammatory cytokines in Bronchoalveolar lavage fluid (BALF) increased in rats exposed to single and repeated inhalations. In the sub-acute test, the changes induced by glycolic acid were minor or returned to normal during the recovery period. CONCLUSION: The No Observed Adverse Effect Concentration (NOAEC) for the nasal and pulmonary toxicity of glycolic acid was determined to be over 50 mg/m3 at the end of a 28-day inhalation test in male rats. Copyright
Authors: M C Kopferschmitt-Kübler; M Blaumeiser-Kapps; M Millet; H Wortham; P Mirabel; P Nobelis; G Pauli Journal: Rev Mal Respir Date: 1996 Impact factor: 0.622
Authors: Roger Renne; Amy Brix; Jack Harkema; Ron Herbert; Birgit Kittel; David Lewis; Thomas March; Kasuke Nagano; Michael Pino; Susanne Rittinghausen; Martin Rosenbruch; Pierre Tellier; Thomas Wohrmann Journal: Toxicol Pathol Date: 2009-12 Impact factor: 1.902
Authors: Jean A Hall; Maha Yerramilli; Edward Obare; Jun Li; Murthy Yerramilli; Dennis E Jewell Journal: PLoS One Date: 2017-04-06 Impact factor: 3.240
Authors: Renjith VishnuRadhan; Divya David Thresyamma; T I Eldho; Ravinder Dhiman; Sreekanth Giri Bhavan Journal: Environ Sci Pollut Res Int Date: 2021-09-14 Impact factor: 5.190