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Literature DB >> 3147082

Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants.

K P Nordal¹, E Dahl, D Albrechtsen, J Halse, T Leivestad, S Tretli, A Flatmark.

Abstract

Aluminium that has accumulated in the body is thought to have a generalised cytotoxic effect. A prospective study of aluminium accumulation in bone-that is, subclinical aluminium toxicity--was carried out in 94 recipients of kidney allografts, who were followed up for three years. Subclinical aluminium toxicity was found in 66 patients. A significantly smaller proportion of patients with aluminium accumulation experienced a rejection episode: 30 (58%) nu 12 (86%) who received grafts from cadavers and 4 (29%) nu 10 (71%) who received grafts from living donors. On multivariate analysis only the source of the kidney and aluminium accumulation were found to influence the rejection rate. These findings suggest that aluminium accumulation has an immunosuppressive effect.

Entities: Chemical Disease Species

Mesh：

Substances：
Aluminum

Year: 1988 PMID： 3147082 PMCID： PMC1835306 DOI： 10.1136/bmj.297.6663.1581

Source DB: PubMed Journal: BMJ ISSN： 0959-8138

14 in total

1. The role of pretransplant blood transfusions.

Authors: B G Solheim
Journal: Transplant Proc Date: 1979-03 Impact factor: 1.066

2. The dialysis encephalopathy syndrome. Possible aluminum intoxication.

Authors: A C Alfrey; G R LeGendre; W D Kaehny
Journal: N Engl J Med Date: 1976-01-22 Impact factor: 91.245

3. Effect of blood transfusions on subsequent kidney transplants.

Authors: G Opelz; D P Sengar; M R Mickey; P I Terasaki
Journal: Transplant Proc Date: 1973-03 Impact factor: 1.066

4. Aluminium poisoning: dialysis encephalopathy, osteomalacia, and anaemia.

Authors: M R Wills; J Savory
Journal: Lancet Date: 1983-07-02 Impact factor: 79.321

5. Bone aluminum and histomorphometric features of renal osteodystrophy.

Authors: A B Hodsman; D J Sherrard; A C Alfrey; S Ott; A S Brickman; N L Miller; N A Maloney; J W Coburn
Journal: J Clin Endocrinol Metab Date: 1982-03 Impact factor: 5.958

6. Dialysis encephalopathy, bone disease and anaemia: the aluminum intoxication syndrome during regular haemodialysis.

Authors: I S Parkinson; M K Ward; D N Kerr
Journal: J Clin Pathol Date: 1981-11 Impact factor: 3.411

7. Water purification and the incidence of fractures in patients receiving home haemodialysis supervised by a single centre: evidence for "safe" upper limit of aluminium in water.

Authors: M M Platts; G Owen; S Smith
Journal: Br Med J (Clin Res Ed) Date: 1984-03-31

8. Hypercalcaemic osteomalacia due to aluminium toxicity.

Authors: B F Boyce; G S Fell; H Y Elder; B J Junor; H L Elliot; G Beastall; I Fogelman; I T Boyle
Journal: Lancet Date: 1982-11-06 Impact factor: 79.321

9. Histological quantitation of aluminum in iliac bone from patients with renal failure.

Authors: N A Maloney; S M Ott; A C Alfrey; N L Miller; J W Coburn; D J Sherrard
Journal: J Lab Clin Med Date: 1982-02

10. The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy.

Authors: S M Ott; N A Maloney; J W Coburn; A C Alfrey; D J Sherrard
Journal: N Engl J Med Date: 1982-09-16 Impact factor: 91.245

6 in total

Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants.

1. The role of pretransplant blood transfusions.

2. The dialysis encephalopathy syndrome. Possible aluminum intoxication.

3. Effect of blood transfusions on subsequent kidney transplants.

4. Aluminium poisoning: dialysis encephalopathy, osteomalacia, and anaemia.

5. Bone aluminum and histomorphometric features of renal osteodystrophy.

6. Dialysis encephalopathy, bone disease and anaemia: the aluminum intoxication syndrome during regular haemodialysis.

7. Water purification and the incidence of fractures in patients receiving home haemodialysis supervised by a single centre: evidence for "safe" upper limit of aluminium in water.

8. Hypercalcaemic osteomalacia due to aluminium toxicity.

9. Histological quantitation of aluminum in iliac bone from patients with renal failure.

10. The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy.

Review 1. Nephrology, dialysis and transplantation.

Review 2. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

3. Aluminium accumulation and immunosuppression.

4. Aluminium accumulation and immunosuppression.

5. Immunotoxicity Following Pre- and Post-natal Aluminum Exposure in Rats.

Review 6. Aluminium toxicosis: a review of toxic actions and effects.