Xiye Wang1, Kaiping Wang1, Juanying Yan1, Minyun Wu2. 1. Department of Gynaecology, People's Hospital of Shengzhou City, Shengzhou, Zhejiang, China. 2. Department of Obstetrics, Quzhou People's Hospital, Quzhou, Zhejiang, China. Electronic address: yunywumin@163.com.
Abstract
BACKGROUND: We aimed to better clarify the relationship between FTO/MTHFR/TCF7L2 polymorphisms and PCOS in a larger combined population by performing a meta-analysis. METHODS: Eligible articles were retrieved from Pubmed, Embase, Web of Science and CNKI. Review Manager Version was used to perform statistical analyses. RESULTS: Forty-six studies were included for this meta-analysis. FTO rs9939609 polymorphism was found to be significantly associated with PCOS under dominant, recessive, over-dominant and allele comparisons, MTHFR rs1801131 polymorphism was found to be significantly associated with PCOS under recessive and allele comparisons, and MTHFR rs1801133 polymorphism was also found to be significantly associated with PCOS under dominant, recessive and allele comparisons in general population. In subgroup analyses, we found that positive results were mainly driven by the Asians. CONCLUSIONS: Collectively, this meta-analysis proved that FTO rs9939609, MTHFR rs1801131 and MTHFR rs1801133 polymorphisms may serve as predisposing factors of PCOS, especially for Asians.
BACKGROUND: We aimed to better clarify the relationship between FTO/MTHFR/TCF7L2 polymorphisms and PCOS in a larger combined population by performing a meta-analysis. METHODS: Eligible articles were retrieved from Pubmed, Embase, Web of Science and CNKI. Review Manager Version was used to perform statistical analyses. RESULTS: Forty-six studies were included for this meta-analysis. FTOrs9939609 polymorphism was found to be significantly associated with PCOS under dominant, recessive, over-dominant and allele comparisons, MTHFRrs1801131 polymorphism was found to be significantly associated with PCOS under recessive and allele comparisons, and MTHFRrs1801133 polymorphism was also found to be significantly associated with PCOS under dominant, recessive and allele comparisons in general population. In subgroup analyses, we found that positive results were mainly driven by the Asians. CONCLUSIONS: Collectively, this meta-analysis proved that FTOrs9939609, MTHFRrs1801131 and MTHFRrs1801133 polymorphisms may serve as predisposing factors of PCOS, especially for Asians.
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