Irene Sanchez1, Francisco Javier Carmona, Sara Gonzalez-Puertas, Angela Valiente, Raul Martin. 1. Departamento de Física Teórica, Atómica y Óptica (I.S., R.M.), Universidad de Valladolid, Valladolid, Spain; Instituto Universitario de Oftalmobiología Aplicada (IOBA) (I.S., R.M.), Universidad de Valladolid, Valladolid, Spain; Optometry Research Group (I.S., S.G.-P., A.V., R.M.), IOBA Eye Institute, School of Optometry, University of Valladolid, Valladolid, Spain; Dpto. de Física Aplicada (F.J.C.), Universidad de Extremadura, Escuela Politécnica, Cáceres, Spain; and School of Health Professions (R.M.), Plymouth University, Plymouth, United Kingdom.
Abstract
OBJECTIVES: The material biocompatibility of hydrogel and silicone hydrogel (SiHy) contact lens (CL) is of paramount importance in CL wear because a decrease in CL wettability reduces wearer comfort and increases wearer dropout. The aim of this study is to report on the repeatability and agreement between two different software programs that measure the contact angle with the captive bubble method in marketed CLs, which will help to translate this information into clinical practice. METHODS: The contact angle of 23 different CLs was measured with the captive bubble method using 2 software programs: FTÅ200 and ImageJ. Three consecutive measurements were conducted for each CL. Reproducibility, repeatability, and agreement values were calculated according to the British Standards Institute and the International Organization for Standardization. RESULTS: All methods showed good repeatability values in both CL materials (coefficient of variation <1.51%, Sw <2.26°, intraclass correlation coefficient >0.89, and the range of limits of agreement was between 7.22° and 7.57°). Higher concordance was achieved between the spherical and nonspherical options when using FTÅ200 software than when using ImageJ software. Statistically significant differences (P<0.05) between the 2 software programs were found, and they ranged between 5° and 10°. CONCLUSIONS: The captive bubble method showed great repeatability in measuring the contact angle in marketed CLs with both software programs (FTÅ200 and ImageJ) assessed in this study. However, differences in the measured contact angles suggest that these techniques are not interchangeable. Therefore, standardization is recommended for contact angle measurement in hydrogel CL materials to facilitate comparisons, to improve clinical use of this information, and to analyze their impact in CL user comfort.
OBJECTIVES: The material biocompatibility of hydrogel and silicone hydrogel (SiHy) contact lens (CL) is of paramount importance in CL wear because a decrease in CL wettability reduces wearer comfort and increases wearer dropout. The aim of this study is to report on the repeatability and agreement between two different software programs that measure the contact angle with the captive bubble method in marketed CLs, which will help to translate this information into clinical practice. METHODS: The contact angle of 23 different CLs was measured with the captive bubble method using 2 software programs: FTÅ200 and ImageJ. Three consecutive measurements were conducted for each CL. Reproducibility, repeatability, and agreement values were calculated according to the British Standards Institute and the International Organization for Standardization. RESULTS: All methods showed good repeatability values in both CL materials (coefficient of variation <1.51%, Sw <2.26°, intraclass correlation coefficient >0.89, and the range of limits of agreement was between 7.22° and 7.57°). Higher concordance was achieved between the spherical and nonspherical options when using FTÅ200 software than when using ImageJ software. Statistically significant differences (P<0.05) between the 2 software programs were found, and they ranged between 5° and 10°. CONCLUSIONS: The captive bubble method showed great repeatability in measuring the contact angle in marketed CLs with both software programs (FTÅ200 and ImageJ) assessed in this study. However, differences in the measured contact angles suggest that these techniques are not interchangeable. Therefore, standardization is recommended for contact angle measurement in hydrogel CL materials to facilitate comparisons, to improve clinical use of this information, and to analyze their impact in CL user comfort.
Authors: María Vivero-Lopez; Andrea Muras; Diana Silva; Ana Paula Serro; Ana Otero; Angel Concheiro; Carmen Alvarez-Lorenzo Journal: Pharmaceutics Date: 2021-04-11 Impact factor: 6.321