Nicola Whiffin1,2,3,4, James S Ware1,2,3,4, Anne O'Donnell-Luria4,5,6. 1. National Heart and Lung Institute, Imperial College London, London, United Kingdom. 2. Cardiovascular Research Centre, Royal Brompton and Harefield NHS Foundation Trust, London, London, United Kingdom. 3. MRC London Institute of Medical Sciences, Imperial College London, London, United Kingdom. 4. Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts. 5. Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts. 6. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston.