Literature DB >> 31468362

Differentially methylated region in bovine MIMT1 detected by small-scale whole-genome methylation sequencing.

Karolina Rutkowska1, Hongen Xu2, Krzysztof Flisikowski3.   

Abstract

We previously showed that deregulation of PEG3 domain genes is associated with intrauterine growth restriction (IUGR) in cattle. Here, we carried out genome-wide DNA methylation analysis of foetal placenta in two IUGR and wild-type samples and identified a differentially methylated region (DMR) in intron 2 of MIMT1. Pyrosequencing on a larger sample size (n = 20) confirmed significantly lower (P < 0.001) MIMT1-DMR methylation in foetal and maternal placenta of IUGR than wild-type conceptuses. Our study demonstrates that small-scale whole-genome bisulphite sequencing can be used to identify epigenetic regulatory elements in a defined genome locus.

Entities:  

Keywords:  Cattle; DNA methylation; Intrauterine growth restriction; PEG3; Placenta

Mesh：

Year:  2019        PMID： 31468362     DOI： 10.1007/s13353-019-00519-6

Source DB:  PubMed          Journal:  J Appl Genet        ISSN： 1234-1983            Impact factor:   3.240


  14 in total

1.  PEG3 domain gene expression in maternal and foetal placenta in intrauterine growth restricted bovine foetuses.

Authors:  Shun Li; Hubert Pausch; Heli Venhoranta; Krzysztof Adamowicz; Magnus Andersson; Lech Zwierzchowski; Alexander Kind; Angelika Schnieke; Krzysztof Flisikowski
Journal:  Anim Genet       Date:  2015-11-05       Impact factor: 3.169

2.  Dysregulation of DNA methylation and expression of imprinted genes in mouse placentas of fetal growth restriction induced by maternal cadmium exposure.

Authors:  Peng Xu; Zhongqiang Wu; Weiwei Yang; Lan Wang
Journal:  Toxicology       Date:  2017-08-18       Impact factor: 4.221

Review 3.  Placental Defects: An Epigenetic Perspective.

Authors:  Sharvari S Deshpande; Nafisa H Balasinor
Journal:  Reprod Sci       Date:  2018-04-11       Impact factor: 3.060

4.  A novel mutation in the maternally imprinted PEG3 domain results in a loss of MIMT1 expression and causes abortions and stillbirths in cattle (Bos taurus).

Authors:  Krzysztof Flisikowski; Heli Venhoranta; Joanna Nowacka-Woszuk; Stephanie D McKay; Antti Flyckt; Juhani Taponen; Robert Schnabel; Hermann Schwarzenbacher; Izabela Szczerbal; Hannes Lohi; Ruedi Fries; Jeremy F Taylor; Marek Switonski; Magnus Andersson
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240

5.  Maternal placenta modulates a deleterious fetal mutation.

Authors:  Hongen Xu; Hubert Pausch; Heli Venhoranta; Karolina Rutkowska; Christine Wurmser; Beate Rieblinger; Tatiana Flisikowska; Dmitrij Frishman; Lech Zwierzchowski; Ruedi Fries; Magnus Andersson; Alexander Kind; Angelika Schnieke; Krzysztof Flisikowski
Journal:  Biol Reprod       Date:  2017-08-01       Impact factor: 4.285

6.  Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain.

Authors:  Joomyeong Kim; An Ye
Journal:  PLoS One       Date:  2016-04-22       Impact factor: 3.240

7.  Identification of an evolutionarily conserved cis-regulatory element controlling the Peg3 imprinted domain.

Authors:  Michelle M Thiaville; Hana Kim; Wesley D Frey; Joomyeong Kim
Journal:  PLoS One       Date:  2013-09-10       Impact factor: 3.240

8.  Alternative promoters of Peg3 with maternal specificity.

Authors:  Bambarendage P U Perera; Joomyeong Kim
Journal:  Sci Rep       Date:  2016-04-14       Impact factor: 4.379

9.  Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates.

Authors:  Sara L Hillman; Sarah Finer; Melissa C Smart; Chris Mathews; Robert Lowe; Vardhman K Rakyan; Graham A Hitman; David J Williams
Journal:  Epigenetics       Date:  2015-01-23       Impact factor: 4.528

10.  Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction.

Authors:  Maian Roifman; Sanaa Choufani; Andrei L Turinsky; Sascha Drewlo; Sarah Keating; Michael Brudno; John Kingdom; Rosanna Weksberg
Journal:  Clin Epigenetics       Date:  2016-06-21       Impact factor: 6.551
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  1 in total

Review 1.  DNA methylation studies in cattle.

Authors:  Jana Halušková; Beáta Holečková; Jana Staničová
Journal:  J Appl Genet       Date:  2021-01-05       Impact factor: 3.240
  1 in total

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