Literature DB >> 31468176

Aluminium in human brain tissue: how much is too much?

Christopher Exley1, Matthew J Mold2.   

Abstract

A burgeoning body of research confirms and affirms the presence of aluminium in human brain tissue. Recently, the first data on aluminium content of brain tissue from donors with diagnoses of familial Alzheimer's disease, autism spectrum disorder, multiple sclerosis and epilepsy have been published. Quantitative data are supported by aluminium-specific fluorescence microscopy identifying the locations of aluminium in human brain tissue. The challenge in the future will be to confirm or refute the role played by brain aluminium intoxication in human neurodegenerative disease.

Entities:  

Keywords:  Aluminium in brain tissue; Aluminium-specific fluorescence microscopy; Alzheimer’s disease; Autism; Epilepsy; Multiple sclerosis; Neurodegenerative disease

Year:  2019        PMID： 31468176     DOI： 10.1007/s00775-019-01710-0

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  10 in total

Review 1.  Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

Authors:  Ramon Cacabelos
Journal:  Int J Mol Sci       Date:  2020-04-26       Impact factor: 5.923

2.  Necrostatin-1 Relieves Learning and Memory Deficits in a Zebrafish Model of Alzheimer's Disease Induced by Aluminum.

Authors:  Xiaocheng Gao; Ping Zhang; Jianping Chen; Lan Zhang; Nan Shang; Jin Chen; Rong Fan; Yanhong Wang; Tao Huang; Qiao Niu; Qinli Zhang
Journal:  Neurotox Res       Date:  2022-01-04       Impact factor: 3.911

3.  Assessment of Aluminum via Baby Foods Consumption in Turkey: Estimated Early-Life Dietary Exposure and Target Hazard Quotient.

Authors:  Burhan Başaran
Journal:  Biol Trace Elem Res       Date:  2021-10-18       Impact factor: 3.738

4.  Imaging of aluminium and amyloid β in neurodegenerative disease.

Authors:  Christopher Exley; Matthew J Mold
Journal:  Heliyon       Date:  2020-04-25

5.  Silicalite-1 Layers as a Biocompatible Nano- and Micro-Structured Coating: An In Vitro Study on MG-63 Cells.

Authors:  Martina Doubkova; Ivana Nemcakova; Ivan Jirka; Vitezslav Brezina; Lucie Bacakova
Journal:  Materials (Basel)       Date:  2019-10-31       Impact factor: 3.623

6.  Household Smoking Status and Heavy Metal Concentrations in Toenails of Children.

Authors:  Shamshad Karatela; Christin Coomarasamy; Janis Paterson; Neil I Ward
Journal:  Int J Environ Res Public Health       Date:  2019-10-12       Impact factor: 3.390

7.  Aluminium co-localises with Biondi ring tangles in Parkinson's disease and epilepsy.

Authors:  Matthew John Mold; Christopher Exley
Journal:  Sci Rep       Date:  2022-01-27       Impact factor: 4.379

Review 8.  Exposure of metal toxicity in Alzheimer's disease: An extensive review.

Authors:  Fahadul Islam; Sheikh Shohag; Shomaya Akhter; Md Rezaul Islam; Sharifa Sultana; Saikat Mitra; Deepak Chandran; Mayeen Uddin Khandaker; Ghulam Md Ashraf; Abubakr M Idris; Talha Bin Emran; Simona Cavalu
Journal:  Front Pharmacol       Date:  2022-08-29       Impact factor: 5.988

Review 9.  Role of metals in Alzheimer's disease.

Authors:  Nikita Das; James Raymick; Sumit Sarkar
Journal:  Metab Brain Dis       Date:  2021-07-27       Impact factor: 3.584

10.  Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders.

Authors:  Matthew John Mold; Adam O'Farrell; Benjamin Morris; Christopher Exley
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472
  10 in total

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