Houda Kaanane1, Nezha Senhaji2, Hind Berradi2, Nadia Benchakroun3, Abdellatif Benider3, Mehdi Karkouri4, Hicham El Attar5, Meriem Khyatti6, Sellama Nadifi2. 1. Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, 20250, Casablanca, Morocco. kaanane.h@gmail.com. 2. Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, 20250, Casablanca, Morocco. 3. Oncology Department, Mohammed VI Center for Cancer Treatment, CHU Ibn Rochd, 20250, Casablanca, Morocco. 4. Anathomo-Pathology Department, CHU Ibn Rochd, 20250, Casablanca, Morocco. 5. Annasr Pathology Center, El Jadida, Morocco. 6. Oncovirology Laboratory, Institut Pasteur du Maroc, 20250, Casablanca, Morocco.
Abstract
PURPOSE: Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will contribute to further understanding the pathogenesis of the disease, thus allowing the development of appropriate targeted treatments. Recently, the link between cancer and inflammation has become more evident and inflammation has been proposed as the seventh hallmark of cancer. Previous studies have suggested that key cytokines involved in inflammation may have an important role in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammation-related genes: IL-6, IL6-R, and IL6-ST, influence lung cancer risk in Moroccan population. MATERIALS AND METHODS: Single nucleotide polymorphisms (SNPs) in IL-6, IL6-R, and IL6-ST genes were assessed in 120 controls and 120 patients with confirmed lung cancer diagnosis. Genotyping analysis was performed with the TaqMan® allelic discrimination technology. The results were analyzed using SPSS 24.0 software. RESULTS: Among the studied SNPs, we found a significant association for the IL-6 (rs2069840) (OR = 1.63; 95% confidence interval 1.08-2.47; p = 0.01). No significant association was observed for the remaining SNPs of IL-6R (rs2228145) and IL-6ST (rs2228044) genes. CONCLUSION: Our results suggest the IL-6 (rs2069840) polymorphism may influence the occurrence of lung cancer in Moroccan patients.
PURPOSE:Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will contribute to further understanding the pathogenesis of the disease, thus allowing the development of appropriate targeted treatments. Recently, the link between cancer and inflammation has become more evident and inflammation has been proposed as the seventh hallmark of cancer. Previous studies have suggested that key cytokines involved in inflammation may have an important role in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammation-related genes: IL-6, IL6-R, and IL6-ST, influence lung cancer risk in Moroccan population. MATERIALS AND METHODS: Single nucleotide polymorphisms (SNPs) in IL-6, IL6-R, and IL6-ST genes were assessed in 120 controls and 120 patients with confirmed lung cancer diagnosis. Genotyping analysis was performed with the TaqMan® allelic discrimination technology. The results were analyzed using SPSS 24.0 software. RESULTS: Among the studied SNPs, we found a significant association for the IL-6 (rs2069840) (OR = 1.63; 95% confidence interval 1.08-2.47; p = 0.01). No significant association was observed for the remaining SNPs of IL-6R (rs2228145) and IL-6ST (rs2228044) genes. CONCLUSION: Our results suggest the IL-6 (rs2069840) polymorphism may influence the occurrence of lung cancer in Moroccan patients.
Authors: Marine Lacroix; François Rousseau; Florence Guilhot; Pauline Malinge; Giovanni Magistrelli; Suzanne Herren; Simon A Jones; Gareth W Jones; Jürgen Scheller; Rami Lissilaa; Marie Kosco-Vilbois; Zoë Johnson; Vanessa Buatois; Walter Ferlin Journal: J Biol Chem Date: 2015-09-11 Impact factor: 5.157
Authors: Elena De Mattia; Erika Cecchin; Marcella Montico; Adrien Labriet; Chantal Guillemette; Eva Dreussi; Rossana Roncato; Alessia Bignucolo; Angela Buonadonna; Mario D'Andrea; Luigi Coppola; Sara Lonardi; Eric Lévesque; Derek Jonker; Félix Couture; Giuseppe Toffoli Journal: Front Pharmacol Date: 2018-04-13 Impact factor: 5.810