Behram Cam1, Murat Sari2, Ahmet Midi3, Ozgül Gergin4. 1. Department of Ear Nose Throat, Acibadem Healthcare Group, Acibadem Kocaeli Hospital, Izmit, Kocaeli, Turkey. 2. Department of Ear Nose Throat, Marmara University, Ministry of Health, Pendik Education and Research Hospital, Istanbul, Turkey. 3. Department of Pathology, Istanbul Bahcesehir University, Faculty of Medicine, Sahrayı cedid mah, Batman sok, no 66, Göztepe, Kadıköy, Istanbul, Turkey. ahmetmidi@yahoo.com. 4. Department of Ear Nose Throat, Ministry of Health, Ümraniye Education and Research Hospital, Istanbul, Turkey.
Abstract
OBJECTIVE: Rhinitis medicamentosa is drug-induced rhinitis which occurs by prolonged and overdose usage of topical nasal decongestants. There is not much of treatment choice rather than nasal steroids. In this pathological study, we have been aimed to represent the healing effects of xylitol on damaged nasal mucosa due to rhinitis medicamentosa. METHOD: 30 Wistar rats were separated into 5 groups. During 2 months, oxymetazoline was given to the first group, and saline was given to second group intranasally. First and second group animals were examined at the end of 2 months and rhinitis medicamentosa was detected. Oxymetazoline was given to the third, fourth, and fifth groups during 2 months. Then xylitol solution, mometasone, and saline were applied, respectively, for 15 days. After the experiment, rats' nasal mucosas were evaluated histopathologically. RESULTS: Xylitol and mometasone were found to be more effective than the control group in terms of histopathological changes. Effectivity of xylitol and mometasone was compared and not a significant value was determined. CONCLUSIONS: According to the results, xylitol solution is effective as mometasone, usable and well-priced in the treatment of rhinitis medicamentosa. More comprehensive and ultrastructural studies on animals and human studies with rhinometric evaluation should be performed.
OBJECTIVE:Rhinitis medicamentosa is drug-induced rhinitis which occurs by prolonged and overdose usage of topical nasal decongestants. There is not much of treatment choice rather than nasal steroids. In this pathological study, we have been aimed to represent the healing effects of xylitol on damaged nasal mucosa due to rhinitis medicamentosa. METHOD: 30 Wistar rats were separated into 5 groups. During 2 months, oxymetazoline was given to the first group, and saline was given to second group intranasally. First and second group animals were examined at the end of 2 months and rhinitis medicamentosa was detected. Oxymetazoline was given to the third, fourth, and fifth groups during 2 months. Then xylitol solution, mometasone, and saline were applied, respectively, for 15 days. After the experiment, rats' nasal mucosas were evaluated histopathologically. RESULTS:Xylitol and mometasone were found to be more effective than the control group in terms of histopathological changes. Effectivity of xylitol and mometasone was compared and not a significant value was determined. CONCLUSIONS: According to the results, xylitol solution is effective as mometasone, usable and well-priced in the treatment of rhinitis medicamentosa. More comprehensive and ultrastructural studies on animals and human studies with rhinometric evaluation should be performed.
Authors: J Zabner; M P Seiler; J L Launspach; P H Karp; W R Kearney; D C Look; J J Smith; M J Welsh Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205
Authors: Christopher L Brown; Scott M Graham; Benjamin B Cable; Egon A Ozer; Peter J Taft; Joseph Zabner Journal: Laryngoscope Date: 2004-11 Impact factor: 3.325