Xingmei Yu1, Lingjun Kong2, Wujun Jiang1, Yinfang Dai1, Yuqing Wang1, Li Huang1, Wei Luo3, Kefang Lai3, Chuangli Hao1. 1. Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou 215003, China. 2. Department of Hematology, Children's Hospital of Soochow University, Suzhou 215003, China. 3. Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
Abstract
BACKGROUND: To comprehensively evaluate the etiology of chronic cough and the value of clinical feature in school age children in Suzhou, China. METHODS: School-age (6-14 years) children newly referred with chronic cough (>4 weeks) were prospectively evaluated by utilizing a diagnostic algorithm in this study. Clinical features of different etiologies of chronic cough were also investigated. RESULTS: In total, 118 patients were enrolled in the study. The cough duration ranged from 1 to 76 months. Upper airway cough syndrome (UACS) was found in 77 (65.3%) patients with chronic cough, cough-variant asthma (CVA) in 57 (48.3%) patients, protracted bronchitis (PB) in 15 (12.7%) patients, gastroesophageal reflux disease (GERD) in 7 (5.9%) patients, tic disorders (TD) in 3 (2.5%) patients and eosinophilic bronchitis (EB) in 2 (1.7%) patients. A single etiology was present in 75 patients and multiple etiologies were present in 43 patients. The three most common single etiologies were UACS (31.4%), CVA (14.4%), and PB (10.2%), followed by GERD (5.9%), and EB (1.7%). The most common multiple etiology was CVA + UACS (31.4%), followed by CVA + PB (2.5%), and TD + UACS (2.5%). CONCLUSIONS: The common etiologies of chronic cough in school-age children were UACS, CVA, and PB, while EB and GERD were rare.
BACKGROUND: To comprehensively evaluate the etiology of chronic cough and the value of clinical feature in school age children in Suzhou, China. METHODS: School-age (6-14 years) children newly referred with chronic cough (>4 weeks) were prospectively evaluated by utilizing a diagnostic algorithm in this study. Clinical features of different etiologies of chronic cough were also investigated. RESULTS: In total, 118 patients were enrolled in the study. The cough duration ranged from 1 to 76 months. Upper airway cough syndrome (UACS) was found in 77 (65.3%) patients with chronic cough, cough-variant asthma (CVA) in 57 (48.3%) patients, protracted bronchitis (PB) in 15 (12.7%) patients, gastroesophageal reflux disease (GERD) in 7 (5.9%) patients, tic disorders (TD) in 3 (2.5%) patients and eosinophilic bronchitis (EB) in 2 (1.7%) patients. A single etiology was present in 75 patients and multiple etiologies were present in 43 patients. The three most common single etiologies were UACS (31.4%), CVA (14.4%), and PB (10.2%), followed by GERD (5.9%), and EB (1.7%). The most common multiple etiology was CVA + UACS (31.4%), followed by CVA + PB (2.5%), and TD + UACS (2.5%). CONCLUSIONS: The common etiologies of chronic cough in school-age children were UACS, CVA, and PB, while EB and GERD were rare.
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