Literature DB >> 31461298

Palladium-Catalyzed Site-Selective C(sp3)-H Arylation of Phenylacetaldehydes.

Bo-Bo Gou1, Hang-Fan Liu1, Jie Chen1, Ling Zhou1.   

Abstract

We describe a Pd-catalyzed selective C-H arylation reaction of phenylacetaldehydes using l-valine as the transient directing group. This process showed a broad substrate scope and excellent selectivity in which a ligand-controlled functionalization of the unactivated β-C(sp3)-H bond. In addition, enantioselective arylation of phenylacetaldehydes was preliminarily explored by utilizing a bulky chiral transient directing group.

Entities:  

Year:  2019        PMID： 31461298     DOI： 10.1021/acs.orglett.9b02650

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Transient Directing Group Enabled Pd-catalyzed γ-C(sp3)-H Oxygenation of Alkyl Amines.

Authors:  Yan-Qiao Chen; Yongwei Wu; Zhen Wang; Jennifer X Qiao; Jin-Quan Yu
Journal:  ACS Catal       Date:  2020-04-24       Impact factor: 13.084

2.  PdII-Catalyzed Site-selective β- and γ-C(sp3)-H Arylation of Primary Aldehydes Controlled by Transient Directing Groups.

Authors:  Yi-Hao Li; Yuxin Ouyang; Nikita Chekshin; Jin-Quan Yu
Journal:  J Am Chem Soc       Date:  2022-03-14       Impact factor: 16.383

3.  Ligand-promoted palladium-catalyzed β-methylene C-H arylation of primary aldehydes.

Authors:  Ke Yang; Zhi Li; Chong Liu; Yunjian Li; Qingyue Hu; Mazen Elsaid; Bijin Li; Jayabrata Das; Yanfeng Dang; Debabrata Maiti; Haibo Ge
Journal:  Chem Sci       Date:  2022-04-25       Impact factor: 9.969

4.  A dual role for acetohydrazide in Pd-catalyzed controlled C(sp3)-H acetoxylation of aldehydes.

Authors:  Juan Chen; Chaolumen Bai; XingWen Tong; Dan Liu; Yong-Sheng Bao
Journal:  RSC Adv       Date:  2020-03-25       Impact factor: 3.361
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.