| Literature DB >> 31456412 |
Monty Montano1,2, Shalender Bhasin1,2, Richard T D'Aquila3, Kristine M Erlandson4, William J Evans5, Nicholas T Funderburg6, Amy Justice7,8, Lishomwa C Ndhlovu9, Bisola Ojikutu10, Marco Pahor11, Savita Pahwa12, Alice S Ryan13,14, Jennifer Schrack15, Michael B Schultz16, Paola Sebastiani17, David A Sinclair16, Julia Tripp18, Bruce Walker19, Julie A Womack8,20, Raymond Yung21, R Keith Reeves19,22.
Abstract
People aging with HIV (PAWH) infection experience greater impairments in physical and cognitive function, in addition to higher rates of peripheral comorbid conditions (e.g., renal failure, diabetes, bone fracture, hypertension, cardiovascular disease, polypharmacy, and multimorbidity). While multifactorial drivers, including HIV infection itself, antiretroviral therapy-related toxicities, disparities in care, and biobehavioral factors, likely contribute, there remains an overarching question as to what are the relevant age-related mechanisms and models that could inform interventions that promote health span and life span in PAWH? This workshop was convened to hear from experts on the biology of aging and HIV researchers studying PAWH to focus on advancing investigations at the interface of HIV and Aging. In this study, we summarize the discussions from the Harvard Center for AIDS Research and Boston Claude D. Pepper cosponsored workshop on HIV and Aging, which took place in October 2018.Entities:
Keywords: HIV; aging; frailty; immune activation
Mesh：
Year: 2019 PMID： 31456412 PMCID： PMC6862961 DOI： 10.1089/AID.2019.0130
Source DB: PubMed Journal: AIDS Res Hum Retroviruses ISSN： 0889-2229 Impact factor: 2.205