Literature DB >> 31455724

SMAC mimetics throw a molecular switch to control TH17 responses.

Stephanie K Dougan1,2, Michael Dougan3,4.   

Abstract

IL-17 produced by TH17 cells plays a central role in numerous protective and pathologic immune responses. In this issue of Science Signaling, Rizk et al. define a molecular switch controlled by the cellular inhibitor of apoptosis proteins that regulates TH17 immunity.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2019        PMID： 31455724     DOI： 10.1126/scisignal.aay3986

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  1 in total

1.  cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes.

Authors:  Kevin Roehle; Li Qiang; Katherine S Ventre; Daniel Heid; Lestat R Ali; Patrick Lenehan; Max Heckler; Stephanie J Crowley; Courtney T Stump; Gabrielle Ro; Anže Godicelj; Aladdin M Bhuiyan; Annan Yang; Maria Quiles Del Rey; Tamara Biary; Adrienne M Luoma; Patrick T Bruck; Jana F Tegethoff; Svenja L Nopper; Jinyang Li; Katelyn T Byrne; Marc Pelletier; Kai W Wucherpfennig; Ben Z Stanger; James J Akin; Joseph D Mancias; Judith Agudo; Michael Dougan; Stephanie K Dougan
Journal:  Sci Transl Med       Date:  2021-05-19       Impact factor: 19.319
  1 in total

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