OBJECTIVE: To assess the gross motor development of children with presumed congenital Zika virus (ZIKV) infection over the first 2 years of their lives. METHODS: Seventy-seven children were assessed at the median ages of 11, 18, and 24 months, using the evaluative instrument Gross Motor Function Measure (GMFM-66). At the third assessment, the children with diagnoses of cerebral palsy (CP) were classified by severity through the Gross Motor Function Classification System (GMFCS) and stratified by topography indicating the predominantly affected limbs. With these instruments in combination and using the motor development curves as reference, the rate of development and functional ability were estimated. RESULTS: At 2 years of age, all children had the diagnosis of CP. Seventy-four (96.1%) presented gross motor skills similar to those of children aged 4 months or younger, according to the World Health Organization's standard. The GMFM-66 median score among the 73 (94.8%) children with quadriplegia and GMFCS level V showed significant change between 11 and 18 months (p < 0.001) and between 11 and 24 months (p < 0.001). No significant difference (p = 0.076) was found between 18 and 24 months. CONCLUSION: Despite showing some gross motor progress during the initial 18 months of life, these children with presumed congenital ZIKV infection and CP experienced severe motor impairment by 2 years of age. According to the motor development curves, these children with quadriplegia have probably already reached about 90% of their motor development potential.
OBJECTIVE: To assess the gross motor development of children with presumed congenital Zika virus (ZIKV) infection over the first 2 years of their lives. METHODS: Seventy-seven children were assessed at the median ages of 11, 18, and 24 months, using the evaluative instrument Gross Motor Function Measure (GMFM-66). At the third assessment, the children with diagnoses of cerebral palsy (CP) were classified by severity through the Gross Motor Function Classification System (GMFCS) and stratified by topography indicating the predominantly affected limbs. With these instruments in combination and using the motor development curves as reference, the rate of development and functional ability were estimated. RESULTS: At 2 years of age, all children had the diagnosis of CP. Seventy-four (96.1%) presented gross motor skills similar to those of children aged 4 months or younger, according to the World Health Organization's standard. The GMFM-66 median score among the 73 (94.8%) children with quadriplegia and GMFCS level V showed significant change between 11 and 18 months (p < 0.001) and between 11 and 24 months (p < 0.001). No significant difference (p = 0.076) was found between 18 and 24 months. CONCLUSION: Despite showing some gross motor progress during the initial 18 months of life, these children with presumed congenital ZIKV infection and CP experienced severe motor impairment by 2 years of age. According to the motor development curves, these children with quadriplegia have probably already reached about 90% of their motor development potential.
Authors: Tatiana Hamanaka; Carla Trevisan M Ribeiro; Sheila Pone; Saint Clair Gomes; Karin Nielsen-Saines; Elizabeth B Brickley; Maria Elisabeth Moreira; Marcos Pone Journal: Viruses Date: 2022-05-28 Impact factor: 5.818
Authors: Lavínia Schuler-Faccini; Miguel Del Campo; Alfredo García-Alix; Liana O Ventura; Juliano André Boquett; Vanessa van der Linden; André Pessoa; Hélio van der Linden Júnior; Camila V Ventura; Mariana Carvalho Leal; Thayne Woycinck Kowalski; Lais Rodrigues Gerzson; Carla Skilhan de Almeida; Lucélia Santi; Walter O Beys-da-Silva; André Quincozes-Santos; Jorge A Guimarães; Patricia P Garcez; Julia do Amaral Gomes; Fernanda Sales Luiz Vianna; André Anjos da Silva; Lucas Rosa Fraga; Maria Teresa Vieira Sanseverino; Alysson R Muotri; Rafael Lopes da Rosa; Alberto Mantovani Abeche; Clairton Marcolongo-Pereira; Diogo O Souza Journal: Front Genet Date: 2022-03-08 Impact factor: 4.599