Literature DB >> 31451829

NIR fluorescent probes with good water-solubility for detection of amyloid beta aggregates in Alzheimer's disease.

Mengyin Xu1, Ruohan Li, Xiang Li, Guanglei Lv, Siping Li, Anyang Sun, Yifeng Zhou, Tao Yi.   

Abstract

Two quinoline-malononitrile-based NIR fluorescent probes with good water-solubility have been developed for detecting and imaging of Aβ aggregates in Alzheimer's disease. In vitro studies demonstrated that both probes exhibited high affinity to Aβ aggregates with an increase of fluorescence intensity due to the intramolecular charge transfer effect. Moreover, the probes could particularly image Aβ plaques in brain sections of triple transgenic AD mice.

Entities:  

Year:  2019        PMID： 31451829     DOI： 10.1039/c9tb01012b

Source DB:  PubMed          Journal:  J Mater Chem B        ISSN： 2050-750X            Impact factor:   6.331


  4 in total

Review 1.  Optical Sensor Array for the Early Diagnosis of Alzheimer's Disease.

Authors:  Fei Li; Callum Stewart; Shijie Yang; Fangfang Shi; Wenyu Cui; Shuming Zhang; Hao Wang; Hui Huang; Mingqi Chen; Jinsong Han
Journal:  Front Chem       Date:  2022-04-04       Impact factor: 5.545

2.  Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes.

Authors:  Jusung An; Peter Verwilst; Hira Aziz; Jinwoo Shin; Sungsu Lim; Ilwha Kim; Yun Kyung Kim; Jong Seung Kim
Journal:  Bioact Mater       Date:  2021-11-09

3.  Targeted and activatable nanosystem for fluorescent and optoacoustic imaging of immune-mediated inflammatory diseases and therapy via inhibiting NF-κB/NLRP3 pathways.

Authors:  Lihe Sun; Juan Ouyang; Zhuo Zeng; Cheng Zeng; Yunqing Ma; Fang Zeng; Shuizhu Wu
Journal:  Bioact Mater       Date:  2021-08-11

4.  Engineering of donor-acceptor-donor curcumin analogues as near-infrared fluorescent probes for in vivo imaging of amyloid-β species.

Authors:  Daqing Fang; Xidan Wen; Yuqi Wang; Yidan Sun; Ruibing An; Yu Zhou; Deju Ye; Hong Liu
Journal:  Theranostics       Date:  2022-04-04       Impact factor: 11.600
  4 in total

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