| Literature DB >> 31451754 |
Zahra Khosravi Babadi1,2, Enge Sudarman3,4, Gholam Hossein Ebrahimipour1, Gian Primahana3,4, Marc Stadler3,4, Joachim Wink5,6.
Abstract
The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC50 value of 5.4 µM.Entities:
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Year: 2019 PMID： 31451754 DOI： 10.1038/s41429-019-0223-7
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649